Electrolyte abnormalities were more common with chlorthalidone
Hypokalemia is a dose-dependent adverse reaction that may develop with chlorthalidone
found no differences from chlorthalidone
in several areas of safety,
The main finding from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), reported in 2002, was that chlorthalidone
was at least as good as lisinopril and amlodipine for preventing fatal coronary heart disease and nonfatal myocardial infarctions (JAMA 288:2981-97, 2002).
5, 2012 /PRNewswire/ -- Results of a 10-week, phase 3 study published online in the American Journal of Medicine found the clinic systolic blood pressure (SBP) reductions of a fixed-dose combination of azilsartan medoxomil and chlorthalidone
were significantly greater at six and ten weeks than those of azilsartan medoxomil co-administered with hydrochlorothiazide.
5 years with either stepped-care chlorthalidone
(2,365 subjects) or placebo (2,371 subjects).
Thiazide diuretics, such as hydrochlorothiazide and chlorthalidone
, are first-line drugs usually prescribed to treat hypertension, as advised by the JNC 7.
Thiazides, such as chlorthalidone
, are an inexpensive and highly effective way to treat high blood pressure and have been used widely for decades.
The Systolic Hypertension in the Elderly Program (SHEP) trial, (11) which had over 4,000 participants, randomized patients ages 60 and over to receive either chlorthalidone
(with the potential addition of atenolol), or placebo.
After 4 years of follow-up, these differences in new-onset diabetes did not translate into more coronary heart disease events, or into higher all-cause mortality, in the chlorthalidone
That's because JNC 7 drew heavily on the results of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), which compared chlorthalidone
with the ACE inhibitor lisinopril and the calcium channel blocker amlodipine.
In a 5-year study at 623 health centers, physicians compared the older drug, the diuretic chlorthalidone
, with the drugs amlodipine and lisinopril.
, hydrochlorothiazide, indapamide, metolazone
June 19, 2012 /PRNewswire/ -- Results of a 12-week, head-to-head, phase 3 study published online in the American Heart Association journal Hypertension found systolic blood pressure (SBP) reductions of a fixed-dose combination of azilsartan medoxomil and chlorthalidone
40/25 mg were statistically superior to those of the fixed-dose combination of olmesartan medoxomil-hydrochlorothiazide 40/25 mg.
Its relative risk (RR) in DM assigned to amlodipine or lisinopril compared with chlorthalidone