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  • noun

Synonyms for chlorambucil

an alkalating agent (trade name Leukeran) used to treat some kinds of cancer


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At 30 months, ibrutinib was also associated with a greater progression-free survival rate of 85% versus chlorambucil, which had a PFS rate of 28%.
In resistant cases cytotoxic agents such as azathioprine, cyclophosphamide and chlorambucil are used in combination with steroids.
10 In patients with comorbidities and older age, combination of chlorambucil plus an anti-CD20 antibody (rituximab, ofatumumab or obinutuzumab) is considered as standard approach.
5% Table 3 Immunosuppressive drugs Table 3 Class Examples Antimetabolites Azathioprine Methotrexate Mycophenolate mofetil Alkylating agents Cyclophosphamide Chlorambucil Antibiotics Cyclosporine Tacromimus Rapamycin Dapsone Adjuvants Bromocriptine Ketoconazole Colchicine
Data from the investigational, randomised, multi-centre, open-label Phase 3 RESONATETM-2 (PCYC-1115) trial show ibrutinib (Imbruvica) was superior to chlorambucil in all efficacy endpoints measured in patients with treatment-naA-ve chronic lymphocytic leukaemia or small lymphocytic lymphoma (CLL/SLL) aged 65 or older, pharmaceutical company Janssen-Cilag International NV said.
Finally, immunosuppressive therapy, such as cyclophosphamide and chlorambucil, and monoclonal antibody therapy with rituximab can also be of some benefit.
Chlorambucil with or without corticosteroids may be considered in patients who may not tolerate combination chemotherapy.
Predisposing Drugs Antituberculosis agents: Isoniazid Pyrazinamide Antiepileptic drugs: Hydantoins Ethionamide Phenobarbital Diazepam Chemotherapy and immunosuppressive drugs 6-Mercaptopurine 5-Fluorouracil Chlorambucil Azathioprine Chloramphenicol
He was treated with chlorambucil and remained stable until February 2010 when he developed a chest infection and was found to have a lymphocyte count of 236x[10.
Professor Chris Fegan, who led trials of the drug at the University of Wales, Cardiff, said: "Gazyvaro shows a significant advantage compared to chlorambucil chemotherapy alone, balancing both efficacy with tolerability.
Gazyva/Gazyvaro is currently approved in more than 40 countries in combination with chlorambucil for people with previously untreated chronic lymphocytic leukemia.
The drug is used in combination with chlorambucil chemotherapy for the treatment of previously untreated patients with lymphocytic leukaemia who have other medical conditions.
In steroid refractory cases, other immunosuppressive drugs found to be effective are Cyclosporine A, Azathioprine, Cyclophosphamide, Chlorambucil, and Mycophenolate mofetil.
Other drugs that inhibit inflammation and/or the immune response, such as chlorambucil, cyclosporine and interferons, may also be used, but these are usually not considered to be the primary treatment of choice.