Professor Anderson said removing iron from the brain using drugs known as iron chelators
represented a very attractive therapy, but better strategies were needed to cross the blood brain barrier the brains defence system.
The efficacy of chelators
is mainly studied from animals.
DMSA or Meso-2,3-dirnercaptosuccinic acid has been used as a heavy metal chelator
since the 1950s, and was extensively researched in the People's Republic of China, Japan, and Russia before it spread to Europe and the USA.
with high antiproliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: A link between iron metabolism and proliferation.
In the zinc or copper chelating assay, the chelator
were able to capture the ions and inhibit the formation of [Zn.
Although the chelators
effectiveness is well reported for phytoremediation, but their effect on plants growth and development and various physiological and biochemical processes has not been inspected in depth.
The use of iron chelators
is an accepted method of removing excess iron from these patients.
All the difficulties in the administration of standard iron chelators
called for attempts to find out new orally active iron chelators
Differential modulation of synaptic transmission by calcium chelators
in young and aged hippocampal CA1 neurons: evidence for altered calcium homeostasis in aging.
During his PhD, Price worked on the design and synthesis of novel chelators
for radioactive metal ions for application in radiopharmaceuticals.
Eat a diet high in antioxidants and increase your intake of natural chelators
(substances that bind the toxins so they can be eliminated by the body), such as green tea and turmeric.
A variety of biological synthetic systems are discussed, including algae, diatoms and chrysophytes, bacteria, and yeasts, as well as processes that utilize nonliving biologically derived components, such as plant extracts to modulate redox properties of the synthetic environment, isolated proteins with useful template shapes, and chelators
to control size.
If only the fast-acting chelator
, BAPTA, can inhibit exocytosis and synaptic transmission, but the slow chelator
EGTA cannot, tight coupling is at work, while in loose coupling, both fast and slow chelators
can inhibit transmission.
The mobilization of NTBI by chelators
from complexes in which NTBI is not available for the bleomycin reagent may explain this discrepancy.
8) Therefore, chelators
, such as EDTA or MPA, may inhibit these OXA enzymes producing a result that could be interpreted as positive for the presence of MBL according to the phenotypic methods.