Extension of resistance to cefepime and cefpirome associated to a six amino acid deletion in the H-10 helix of the cephalosporinase
of an Enterobacter cloacae clinical isolate.
Role of efflux pumps: MexAB-OprM and MexXY (-OprA), AmpC cephalosporinase
and OprD porin in non-metallo-[beta]-lactamase producing Pseudomonas aeruginosa isolated from cystic fibrosis and burn patients," Infection, Genetics and Evolution, vol.
For checking the production of cephalosporinase
enzyme bacterial lawn was prepared on MH agar and 30g discs of Ceftazidime Cefuroxime Cefotaxime and Aztreonam were placed for 24 hours on 370C.
Figure 2: Cephalosporinase
/penicillinase induced neutralization of 13 [beta]-lactam antibiotics which inhibit growth of Kocuria rhizophila ATCC 9341 on TSA contact plates Reference without With cephalosporinase cephalosporinase
and penicillinase or penicillinase (medium contains (medium contains lecithin end Tween 80) lecithin.
The presence of extended-spectrum cephalosporinase
activity was evaluated within Puerto Rico using surrogate markers of cephalosporin susceptibilities across generations (Table 2).
Extended spectrum beta-lactamases and cephalosporinase
production were phenotypically determined.
Penicillin and cephalosporins are not recommended for initial treatment due to the demonstration of a cephalosporinase
and an inducible penicillinase in the anthrax genome.
anthracis strains produce a cephalosporinase
and suggest that the strains contain an inducible beta-lactamase that might decrease the effectiveness of penicillins, especially when a large number of organisms is present (2).
chromosomal AmpC cephalosporinase
induction/derepression or porin modification) as the basis in Enterobacter species.
These isolates could be IRT or OXA enzymes or cephalosporinase
These antibiotics are not readily affected by cephalosporinase
or penicillinase enzymes produced by certain bacteria .
The susceptibility pattern with regard to cefepime probably reflects excellent activity against chromosomal-located cephalosporinase
These preliminary studies indicate the presence of a class B cephalosporinase
and suggest that a penicillinase also may be present.
4) In Enterobacteriaceae, antibiotic resistance due to the production of extended-spectrum 0-lactamase (ESBL-E) and overexpression of AmpC cephalosporinase
(AmpC-E) is cause for great concern and produce a significant impact both on empirical and definitive therapy.
was slightly more active against cephalosporinase
as compared to clavulanic acid.