centromere


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  • noun

Synonyms for centromere

a specialized condensed region of each chromosome that appears during mitosis where the chromatids are held together to form an X shape

References in periodicals archive ?
A cutoff for RAI1 gains was not used because of the assumption that cases with gains in HER2, the centromere, and RAI1 were unlikely to represent true HER2 amplification.
The Tau sequence was inserted downstream of the centromere protein C (CENP-C) promoter to drive expression of the reporter.
A high frequency of metacentric chromosomes was observed in the complements of the 12 accessions, which is indicated by the average values of the centromere indices (CI) and ratios obtained between the arms of the chromosomes (r) (Table 1).
The SDR gametes contain sister chromatids from the centromere to the
com)-- During mitosis, spindle fibers attach to the centromere via the kinetochore.
The findings that C-bands localize in the centromere and telomere regions of the chromosomes in A.
The chromosome enumeration probes hybridizing to the centromere of the relevant chromosomes (LPE007R, Alpha satellite 7 Red; LPE017R, Alpha satellite 17 Red; LPE0YcR, Alpha satellite Y Red) were labelled with spectrum red.
The way in which a vital protein is loaded by others into the centromere, the part of the chromosome that plays a significant role in cell division, has been identified by biologists.
The centromere is the chromosomal domain that directs the formation of the kinetochore, a proteinaceous structure that interacts with the spindle microtubules to ensure proper chromosmal segregation.
IHC scoring (0, 1 + ,2 + ,3 +)is based on the relative intensity of tumor cell membrane staining with the HER2 antibody, whereas FISH scoring is based on counting the signals corresponding to immobilized fluorescent HER2 and chromosome 17 centromere (CEP17) hybridization probes.
Normal human chromosomes are linear in structure consisting of two "arms" (designated "p" and "q") that flank a single active centromere.
Micronuclei were scored as centromere negative (clastogenic) or centromere positive (aneugenic) based on the presence of CREST staining, which recognizes centromere proteins within the kinetochore of each chromosome, within each micro-nucleus.
HER-2/neu gene amplification was determined by FISH according to Path Vysion (Vysis, Inc) in paraffin embedded tissue sections as a ratio of HER-2/neu gene copies-to chromosome 17 centromere copies.