The histologic differential diagnosis of hyalinizing Spitz nevus includes dermatofibroma, desmoplastic cellular blue nevus
, metastatic carcinoma, and malignant melanoma.
The epithelioid cells are reminiscent of cells forming cellular areas in cellular blue nevus.
First described by Seab et al, (43) this entity causes significant confusion owing to its resemblance to a pigmented Spitz nevus, BN, malignant melanoma, and cellular blue nevus.
Cellular blue nevus (CBN) was established as a distinct entity by Allen and Spitz, (44) Allen, (45) and Rodriguez and Ackerman.
Artur Zembowicz, MD, PhD, and Pushkar Phadke, MD, PhD, review clinical and histologic features of blue nevus, cellular blue nevus
, and malignant blue nevus, emphasizing recently described variants and critical differential diagnoses.