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  • noun

Words related to cytotoxicity

the degree to which something is toxic to living cells

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The effects of the immunotherapy on natural killer cell-mediated cytotoxicity were explored by assessing the release of LDH from the tumor cells after challenge with the natural killer cells in the splenocyte population.
Bottino, “Antibody-dependent cell-mediated cytotoxicity (ADCC) is thought to augment the efficacy of IgG1 mAb therapeutics (eg.
Abbreviations Used Explanation FIP1L1-PDGFRA FIP1-like 1-Platelet derived growth factor receptor type A TTP Thrombotic Thrombocytopenic purpura HES Hypereosinophilic syndrome ADAMTS-13 A Disintegrin-like and Metalloprotease with Thrombospondin Type 1 Motif, 13 MAHA Microangiopathic hemolytic anemia VWF Von Williebrand factor LDH Lactate dehydrogenase PEX Plasma exchange FISH Florescent in-situ hybridization CHIC2 Cysteine-rich hydrophobic domain 2 RT-PCR Reverse transcriptase-polymerase chain reaction ADCC Antibody dependent cell-mediated cytotoxicity Table.
K] monoclonal antibody--is specific for the CD20 antigen and can selectively deplete B-cells via antibody-dependent cell-mediated cytotoxicity, complement-mediated cytotoxicity, and inhibition of cell proliferation with direct induction of B-cell apoptosis.
GTC reported yesterday in a news release that the result demonstrated its ability to produce monoclonal antibodies with antibody-dependent cell-mediated cytotoxicity, a feature useful in treating cancer and autoimmune disorders.
Cell-mediated cytotoxicity in hepatitis A virus infection.
Enlists immune cells to attack and kill tumour target cells via antibody-dependent cell-mediated cytotoxicity.
Antibody-dependent cell-mediated cytotoxicity (ADCC): A mechanism of cell-mediated immunity whereby certain immune cells actively break up a target cell that has been bound by specific antibodies.
Results: [gamma][delta] T cell-mediated cytotoxicity is inhibited by blocking PI3-kinase with wortmannin or LY294002.
Antibody-dependent cell-mediated cytotoxicity (ADCC) is the main MOA of antibodies through which virus-infected or other diseased cells are targeted for destruction by components of the cell-mediated immune system, such as natural killer cells.
By retaining a native Fc-region, avelumab is thought to potentially engage the innate immune system and induce antibody-dependent cell-mediated cytotoxicity (ADCC).
Binding to Fc receptors and complement mediates antibody-dependent cell-mediated cytotoxicity and is an important mechanism of action for mAbs.
ALT-803 also potently activates NK cells and enhances antibody-dependent cell-mediated cytotoxicity of antibodies in various experimental models.