"We noticed that nuclear domains named paraspeckles"--i.e, structures in the cell nucleus
that can be visualized by fluorescence microscopy--"do not occur in iPS cells, but are quickly formed during the differentiation process, irrespective of the cell type that we created," said Miha Modic.
As indicated in Figure 4, pGH was localized to the cell membrane, mitochondria and cell nucleus
To capture this dynamic, the scientists used a state-of-the-art fluorescent microscope that enables them to see extremely small and very fast shape changes of the cell nucleus
in living cells.
Most HDACs are activated in the cell nucleus
but HDAC6 mainly affect the cell function outside the cell nucleus
He replaced the immature cell nucleus
in an egg cell of a frog with the nucleus from a mature intestinal cell.
Gepstein's team took skin cells from two men with heart failure and transformed them by adding three genes, and then a small molecule called valproic acid to the cell nucleus
As a result of these changes, the protein is retained in the cell nucleus
, where it facilitate the carcinogenic process, and this is the point at which vitamin D intervenes, or rather, the vitamin D receptor (VDR).
One important way of blocking NF-kB activity is to prevent it from becoming activated by moving into the cell nucleus
. That denies NF-kB access to the pro-inflammatory genes that it regulates, thereby preventing the inflammatory response before it starts.
Mitochondria DNA is separate from that of the cell nucleus
and contains far fewer genes.
"Xanthohumol prevented the receptor from translocating to the cell nucleus
, thus inhibiting its potential to stimulate the secretion of PSA and other hormone-dependent effects," Gerhauser said.
Researchers have identified several genes whose spatial position inside the cell nucleus
is altered in invasive breast cancer when compared to normal breast tissue.
In a study showing how far they can penetrate living tissue, the Euro 2.8 million MAGSELECTOFECTION study showed once nanoparticles enter a cell, they move randomly until collected by proteins, which take them to the cell nucleus
. The research was staged to help drug companies develop targeted delivery of pharmaceuticals with nanoparticles.
The whole technology arena has evolved from loading nanoparticles with compounds used to fight diseases just a few years ago to the current use of carbon nanotubes (CNTs) and other nanostructures as carriers for drugs that can penetrate cell walls and even the cell nucleus
When progesterone binds to the receptor, it sends a signal that's transferred to the cell nucleus
. Progesterone typically instructs a cell to proliferate.