Discovery and validation of cell cycle
arrest biomarkers in human acute kidney injury.
Conclusion: The current study strongly reveals that rosamultic acid inhibits gastric cancer proliferation by inducing apoptosis mediated through cell cycle
arrest, downregulation of cell cycle
related protein expressions, inhibition of cell migration, DNA damage, and activation of caspases.
Close analysis showed that sulforaphane induced G2/M cell cycle
arrest, higher p21 levels, cleavage of PARP and caspases (3, 8 and 9), and the inhibition of AKT/mTOR signalling in ALL cells.
Dysregulated cell cycle
control is a fundamental characteristic of cancers (2).
The best described action of CDT is its ability to inhibit cell cycle
progression by blocking intoxicated cells in G2 phase (8).
The cell cycle
is an ordered series of events culminating in cell growth and division into two daughter cells.
6,753,329) claims the composition of matter of a family of cell cycle
inhibitors that includes RGB-286199.
The therapeutic alkyl imidates, methyl acetimidate (MAI) and dimethyl adipimidate (DMA) induce perturbations in cell cycle
progression and loss of cell viability in cultured human lymphocytes and Chinese hamster cells.
IncellDx scientists presented data using IncellDx's proprietary OncoBreast 3Dx[TM] technology to multiplex protein markers for tumor type (E-cadherin) and ER status, markers for her-2 neu protein and mRNA as well as DNA cell cycle
and ploidy, all in intact tumor cells in suspension.
Downstream effects such as cell cycle
and apoptosis-related mechanisms have not been analyzed yet.
Which stem cell-specific genes alter the cell cycle
Occasionally, particularly in older organisms, cells with defective BRCA1 or BRCA2 genes would also experience mutations in the genes needed to arrest the cell cycle
Just a half century ago the framework of the cell cycle
with its four phases was created by Howard and Pelc (1951).
The aim of this proposal is to identify the role played by members of the rho-subfamily in controlling integrin-dependent signal transduction pathways active during G1 phase of the cell cycle
05) and resulted in significant cell cycle
arrest in the G1 and G2/M phases after 72 h of treatment at concentrations over 5 and 10 [micro]M in MCF-7 and MDA-MB-453 cells, respectively (p < 0.