The double-blind, randomized, controlled, multicenter study was conducted over a 24-month period in which researchers observed and treated 194 patients with symptomatic primary knee osteoarthritis (OA) with either chondroitin sulfate (CS) (1,200 mg/day), or celecoxib
(CE) (200 mg once daily).
The latest research has shown that among all the NSAIDs, celecoxib
reports the lowest number of cases of gastrointestinal side effects.
The double-blind Multicentre Osteoarthritis interVEntion trial with SYSADOA (MOVES) was conducted in France, Germany, Poland and Spain, evaluating treatment with CS+GH versus celecoxib
in 606 patients with Kellgren and Lawrence grades 2-3 knee osteoarthritis and moderate-to-severe pain (Western Ontario and McMaster osteoarthritis index (WOMAC) score [greater than or equal to] 301; 0-500 scale).
Side effect profiles and tolerability were similar with glucosamine / chondroitin (Droglican) and celecoxib
(Celebrex), with 51% of patients overall having treatment-emergent adverse events, Dr.
We are pleased with the reissuance of this patent protecting the invention of using celecoxib
to treat osteoarthritis and other approved conditions, and have initiated legal proceedings to enforce our intellectual property rights through December 2, 2015.
Non-steroidal anti-inflammatory drugs (NSAID), such as celecoxib
, act as COX-[epsilon] inhibitors and are widely used for osteoarthritis.
We consistently saw that the risk of having a spontaneous abortion was associated with gestational use of diclofenac, naproxen, celecoxib
, ibuprofen and rofecoxib alone or in combination, suggesting a class effect," he stated.
Patients were allocated to naproxen, ibuprofen, diclofenac, celecoxib
, etoricoxib, rofecoxib, lumiracoxib, or placebo.
US scientists conducting the new study looked at the effect of celecoxib
on 240 people who already had actinic keratosis, pre-cancerous skin damage.
belongs to the same drug family as Vioxx, withdrawn from the market following similar concerns.
The study focused on three nonselective NSAIDs, ibuprofen, diclofenac, and naproxen; and on two COX-2 selective NSAIDs, rofecoxib (Vioxx) and celecoxib
Naproxen and celecoxib
failed to prevent Alzheimer's disease in the first clinical trial to test the agents as preventives in older subjects who had no cognitive impairment, wrote Barbara K.
A combination of a low dose of atorvastatin (Lipitor) and a low dose of celecoxib
(Celebrex) potently inhibits the androgen-independent growth of prostate cancer in an animal model, according to research reported at the American Association of Cancer Research 2008 annual meeting in San Diego.
The RR for rofecoxib is not demonstrated in many other trials assessing cardiovascular risk with celecoxib
and non-selective NSAIDs that generated risk ratios of less than 2.
In addition, cyclooxygenase-2 (COX-2) selective inhibitors have become available; of the latter drug class, only celecoxib
is on the market in the U.