Since 2010, the recommended treatment for gonorrhea has consisted of a single ceftriaxone
shot and an oral dose of azithromycin; having a cluster with increased resistance to both is problematic on several levels, infectious disease experts say.
Treatment Details: Ceftriaxone
(75 mg/kg) was started as the initial drug of choice and later if there was no clinical response Ofloxacin (10 mg/kg) and/or Azithromycin (10 mg/kg) were added.
The use of antibiotics previously thought to be ineffective may slow the emergence of ceftriaxone
resistant infections by alleviating the selective pressure.
9) reported that ceftriaxone
is an alternative to penicillin for treatment of neurosyphilis or early syphilis among HIV-infected patients.
In patients with HIV, the treatment is same: Ceftriaxone
250 mg single intramuscular dose plus azithromycin 1 g single oral dose.
The drug in question, known as ETX0914, is a single-dose oral therapy that would substitute for ceftriaxone
in the currently recommended treatment protocol.
The CDC reported finding seven first-time cases of gonorrhea in Hawaii resistant to azithromycin and less susceptible to ceftriaxone
, the last effective treatments.
In 2008, the CLSI recommended new breakpoints for the minimum inhibitory concentrations (MICs) of penicillin and ceftriaxone
, proposing different interpretive criteria for determining the use of the two antibiotics in treating meningeal and non-meningeal infections.
Currently, the company's Phase 2b proof-of-concept, randomized, placebo-controlled clinical trial is underway to evaluate the ability of ribaxamase to prevent CDI and AAD in patients hospitalized with a lower respiratory tract infection and receiving IV ceftriaxone
If this azithromycin-resistant strain of gonorrhoea became widespread then ceftriaxone
would be the only antibiotic left for doctors to prescribe.
However, resistance to azithromycin has developed and is spreading, and experts fear it's only a matter of time before ceftriaxone
The patient was admitted to the hospital, and treatment with 2 g intravenous ceftriaxone
once daily was initiated.
Enhanced gonorrhea susceptibility to third-generation cephalosporin-class antibiotic agents such as injectable ceftriaxone
and oral cefixime may have been temporary, according to a retrospective analysis.
In group 1 (n= 13), injection Ceftriaxone
@ 10 mg/kg b.
The patient had been receiving ceftriaxone
for 2 days.