caspase


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Related to caspase: Caspase 3, Caspase 9
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  • noun

Words related to caspase

any of a group of proteases that mediate apoptosis

References in periodicals archive ?
Metformin protect against PTZ-induced apoptotic neurodegeneration: Mitochondrial changes occurs after the activation of caspases pathway.
In contrast to T47D cell lines, MCF7 cell lines with tiliroside of 50 [micro]g/ml occurred weak expression of Caspase 8 (Figure 6) moreover Caspase 9 was not expressed.
Caspases are activated in a hierarchy order, in which initiator caspases (caspase-8 and -10) function to cleave effector caspases (caspase-3 and -7), the latter in turn degrade a number of intercellular protein substrates and lead to the classical morphological changes of apoptosis (Figures 1 and 2) [5,6].
Immunohistochemical staining performed on 4-[micro]m, formalin-fixed, paraffin-embedded sections using P53 & Caspase 3 antibodies at 1:50 dilution (DAKO, Carpinteria, CA).
Adam, "Inhibition of caspase activity induces a switch from apoptosis to necrosis," FEBS Letters, vol.
Caspases are cysteine proteases that play crucial role in apoptotic cell death.
The researchers determined that Legionella pneumophila bacteria somehow suppress activation of caspases 4 and 5 in human cells but, if the enzymes are added back into immune cells, they set off the same fusion events--those also seen in mice --that will kill the bacteria.
Measured responses included activation of ERK and JNK, mitogen-activated protein kinases involved in cell growth, proliferation, and apoptosis (programmed cell death); activation of caspases 8 and 9, enzymes that also are involved in apoptosis; and release of prolactin, a hormone that helps regulate hundreds of biological functions, including metabolism, reproduction, and lactation.
Various methods to inhibit apoptosis including the cell surface Fas receptor (FAS) pathway inhibitors (also known as CD95L pathway inhibitor), caspase inhibitors, overexpression of anti-apoptotic genes and small interfering ribonucleic acid (RNA) therapy are discussed.
Caspase activity was determined on the basis of transformed ability of caspase 3, 8 and 9 (Beyotime, China).
The overreactors ramp up production of an executioner protein called caspase and eventually commit cellular suicide.
The members of evolutionarily conserved inhibitor of apoptosis protein (IAP) family are endogenous caspase inhibitors and inhibit apopotosis.
Caspase is a family of cysteine proteases, with specific cysteine residue that cleaves proteins after the aspartic acid residue, a specificity which is not normal among proteases to produce the active mature caspases [5].
Specific topics include the age-dependence of neuronal apoptosis and of caspase activation, the significant role of apoptosis-inducing factor for brain damage following focal cerebral ischemia, the role of [micro]-calpain I and lysosomal cathepsins in hippocampal neuronal necrosis after transient global ischemia in primates, mitochondrial damage in traumatic central nervous system injury, hypoglycemic neuronal death, and the suspected role of a multi-functional protein--Tumor Suppressor p53--in seizure-induced neuronal cell death.
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