Grade 1 chondrosarcomas consist of profuse hyaline cartilage matrix
surrounding a little cellular mass and metastasize infrequently (1).
Factors secreted by osteoblasts isolated from sclerotic bone, but also mononucleated cells that are present in the bone marrow, have been shown to influence chondrocyte metabolism indicated by a reduction of cartilage matrix
synthesis in a co-culture model (Sanchez et al.
Chondroitin Sulfate (CS) is also involved in the formation of cartilage matrix
This disease is the result of the metabolic imbalance of cartilage matrix
biomolecules which appears in the degradation exceeding synthesis .
Its products include vericart auto-regenerative cartilage matrix
and neocart implant.
Moreover it has been recently reported that in OA due to mitochondrial dysfunction several pathways including oxidative stress, up-regulated chondrocyte cytokine-induced inflammation and matrix catabolism, pathologic cartilage matrix
calcification, and increased chondrocyte death are implicated in cartilage degradation (Blanco etal.
In an alternative approach, other researchers are testing the scaffold potential of a cartilage matrix
obtained from cadavers.
Parameters studied included the number of cells /unit area in control, immobilised and re-mobilised groups; and the intensity of staining in control, immobilised and re-mobilised groups using Alcian Blue stain for evaluating cartilage matrix
When matrix production by the chondrons is visualized with an alcian blue and nuclear fast red technique, cartilage matrix
containing sulfated proteoglycans appears blue, and cell nuclei appear red.
it seems realistic to consider that an increased concentration of glucose in the diabetic cartilage matrix
environment would lead to the same deleterious result.
Following an ACL injury, there is evidence of cartilage matrix
disruption, chondrocyte death, accelerated chondrocyte senescence, and changes in cell metabolism (Clin.
Glucosamine is a normal constituent of glycosaminoglycans in cartilage matrix
and synovial fluid.
In the cartilage matrix
, the volume occupied by PG is limited by the entangling collagen framework.
Repetitive microtrauma creates biomechanical alterations in the cartilage matrix
5-kDa HA-fs enhance MMPs, including MMP -3 and 13 but not an ADAMTS-5 in chondrocytes and cartilage explant cultures, to a lesser extent than a Fn-f, included as a positive control, but enhance cartilage matrix
damage to a similar extent as Fn-f.