Researchers of University of Bristol found that by removing the carotid body
connection to the brain in rodents with high blood pressure, blood pressure fell and remained low.
The majority were again carotid body
tumors, at 60% of head and neck paragangliomas in this particular series (10).
A 47 years old woman was found to have a carotid body
tumor in an angiographic study (Figure 2a).
tumors are composed by two cells types: the type I cells are the chief or paraganglionic cells; the type II cells are the sustentacular cells.
For example, paragangliomas of the adrenal medulla are pheochromocytomas, and paragangliomas of the carotid bifurcation are carotid body
More carotid body
cells survived in the recent experiment on monkeys, Lopez-Barneo says.
Proceeds from the financing will be used to support development of Cibiem's proprietary, minimally invasive, catheter-based approach focused on Carotid Body
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Since chronically hypoxic patients often develop paragangliomas arising from the carotid body
, a critical site of oxygen sensing, activation of hypoxia-inducible pathways appears to be essential to the pathogenesis of these tumors and may greatly contribute to their hypervascularity.
1) The carotid body
is the most common site for these tumours to arise, and these carotid body
tumours characteristically splay the internal and external carotid arteries.
Cardiovascular/Peripheral Vascular Surgery: Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy; Aortic Aneurysm Repair - Criteria and Options; Aortic and/or valve replacement; Atherectomy, peripheral; Atrial septal defect, repair; Carotid body
tumor resection (Glomectomy); Carotid endarterectomy - Indications, LOS; Carotid/Vertebral Artery Angioplasty and Stenting Procedures; Coronary artery bypass graft(s) surgery (CABG) - Indications, LOS; Extracranial-Intracranial arterial bypass surgery; Heart volume reduction surgery;
2) When they do occur in the head and neck, the most common locations are the carotid body
at the bifurcation of the common carotid artery (carotid body
tumor), the jugular bulb (glomus jugulare), the tympanic plexus (glomus tympanicum), and the vagus nerve ganglia (glomus vagale).
Magnetic resonance imaging of the head and neck demonstrated multiple skull base lesions consistent with bilateral carotid body
tumors, a left glomus jugulare, and a right glomus vagale.
In the poststyloid space, they are associated with the carotid body
, the jugular bulb, or the vagus nerve.
The first case involved a poorly differentiated metastatic carcinoma of oropharyngeal origin that mimicked a carotid body
High on the list of working differential diagnoses were glomus vagale, schwannoma, neurofibroma, squamous cell carcinoma, and carotid body