They have succeeded in loading cardiac muscle
cells onto a three-dimensional scaffold, created using the silk produced by a tropical silkworm.
Together, the results suggest that a defect in oxidative phosphorylation can result in the skeletal and cardiac muscle
symptoms characteristic of mitochondrial disease.
The study is based upon another recent discovery in the Chien lab showing that VEGFA, a known growth factor for vascular endothelial cells in the adult heart, can also serve as a switch that converts heart stem cells away from becoming cardiac muscle
and towards the formation of the coronary vessels in the fetal heart.
1 [micro]g/L) concentrations of cTnT even when no cardiac muscle
injury could be detected .
September 5, 2013 -- Pure cardiac muscle
cells, ready to transplant into a patient affected by heart disease are the Holy Grail for many cardiology researchers working with stem cells.
The short term application is directed towards the treatment of patients with peripheral vascular disease, the company said, while the long term application is focused on the healing and regeneration of cardiac muscle
following acute myocardial infarction or chronic heart failure.
Our data show that this hydrogel can increase cardiac muscle
and reduce scar tissue in the region damaged by the heart attack, which prevents heart failure.
AMR-001 is an autologous bone marrow derived, CD34 positive selected stem cell product that limits progressive cardiomyocyte loss after AMI and has the potential to maintain cardiac muscle
function and prevent adverse cardiac events.
The company says the partners will focus initially on developing a treatment in which a patient's own cardiac muscle
cells-called cardiomyocytes-are used to replace damaged heart tissue.
New research indicates that vessel-opening strategies can also prevent potentially fatal abnormal electrical patterns in cardiac muscle
-- patterns common in the weeks and months following a heart attack.
A few animals treated with Aspirin showed mild fatty changes in the cardiac muscle
fibers of heart and mild catarrhal changes of gastric mucosa, whereas, none of the animals treated with PLATROL(R) showed any such change.
In this study, the team examined the role of matrix elasticity on cardiac muscle
development using mouse and human embryonic stem cells, which were grown on different substrates of a silicon-based organic polymer that varied in stiffness.
Fibrosis impedes regeneration of cardiac muscle
cells, and contributes to loss of contractile function, ultimately leading to heart failure and death.
The PATHFAST cTnI-II test determines the quantity of cardiac troponin I, a protein that is integral to cardiac muscle
contraction, which is elevated in the bloodstream after damage to the myocardium (the middle and thickest layer of the heart wall).
Six alcoholics with severely weakened hearts underwent diagnostic biopsies, all of which revealed multiple signs of cardiac muscle
breakdown due to alcohol, Rubin says.