It is theorised that the hypoinsulinaemic state induced by CCBs prevents glucose uptake into the cardiomyocytes, starving them of their energy substrate, further impairing cardiac contractility
Effect of tidal volume, sampling duration, and cardiac contractility
on pulse pressure and stroke volume variation during positive-pressure ventilation.
Phosphoinositide 3-kinase c Regulates Cardiac Contractility
by Locally Controllig Cyclic Adenosine Monophosphate Levels.
Despite lack of satisfactory data in subclinical hypothyroidism patients having ACS treatment with levothyroxine may be found fruitful as it might lower cholesterol lever and can improve cardiac contractility
The M mode echocardiographic image of a dog with distributive shock caused by pancreatitis showing the impairment in cardiac contractility
can be seen in figure 2A.
These inflammatory mediators ultimately lead to coronary vasospasm, increased cardiac contractility
and heart rate, increased platelet aggregation, and increased plaque disruption.
Autonomic modulation and cardiac contractility
in vasovagal syncope.
SERCA pump level is a critical determinant of Ca(2 +)homeostasis and cardiac contractility
. J Mol Cell Cardiol 2001; 33:1053-1063, doi: 10.1006/ jmcc.2001.1366.
However, long-term hypocalcemia can seriously impair cardiac contractility
and heart failure cannot be controlled without hypocalcemia.
Pressure overload also resulted in a marked reduction in cardiac contractility
, as measured by dP/dT max and dP/dT min (Figure 1(b)).
Using the RUSH protocol, one can evaluate cardiac contractility
, pericardial effusion or signs of tamponade, and IVC diameters with respiration/ventilation to differentiate types of shock (Table 1) [3-5] or to evaluate potential causes of hypotension during hemodialysis or ultrafiltration.
This finding is also supported by the use of myocardial performance index (MPI) in order to evaluate global cardiac contractility
, since it was demonstrated that an altered MPI is the earliest echocardiographic change in DCM, with recorded higher values in DCM patients compared with controls .
Inflammation and oxidative stress also directly impair cardiac contractility
Interactions of DPP-4 inhibitors with the cardiovascular system and cardiomyocytes were successfully revealed, yet a direct link between DPP-4 inhibitors and its effects on cardiac contractility
and/or electrophysiological function is still unknown, and the corresponding downstream mechanisms have yet to be determined.
These effects appear to be related to the stimulated release of neurotransmitters including dopamine, serotonin, and/or noradrenaline [1,10], with noradrenaline acting via alpha-1 receptors in arterial vasculature to stimulate vasoconstriction and via beta-1 receptors to increase cardiac contractility
and heart rate , leading to hypertension and tachycardia, and promoting cardiac ischaemia.