According to the company, the implantable Optimizer delivers non-excitatory cardiac contractility
modulation signals to the heart muscle and initiates multiple biochemical and neurohormonal changes to the myocardium.
Caption: Figure 2--Echocardiographic images showing (A) the impairment in cardiac contractility
evidenced by the arrows, in which the left ventricle cavity does not suffer much change in its diameter comparing systole (short arrow) and diastole (long arrow), in a dog with distributive shock (right parasternal short axis image at the level of chordae tendinea); (B) an enlarged left atrium (dotted line) (left atrium-to-aorta ratio >2.
The cardiovascular response to this drug was essential: it improved cardiac contractility
and arterial pressure thereby obtaining optimal physiological conditions that permitted the tumor resection with adequate results (Figs.
ROS affect cardiac contractility
and survival [4, 7, 25-30].
In patients with hyperthyroidism, cardiac contractility
, cardiac output, and ejection fraction were found to be sharply elevated with a decrease in diastolic function.
In response to the lower concentrations of the endogenously synthesized NO through eNOS activation, a positive inotropic effect is achieved, which contributes to the maintenance of cardiac contractility
under basal physiological conditions.
Modulation of cardiac contractility
by the phospholamban/SERCA2a regulatome.
New positive inotropic agents with higher safety margins and stronger effects on cardiac contractility
have been introduced in human and veterinary cardiology during the last 20 years (3) and their use must be explored in the avian patient.
Phospholamban: a crucial regulator of cardiac contractility
Spontaneous hypertension in rats does not change (7) or increase (8) the indices of cardiac contractility
Our previous studies on the rat heart suggested that, under basal conditions, nitrite represents a nitric oxide synthase(NOS-) independent source of NO, which modulates cardiac contractility
through the classic cGMP/PKG pathway .
Dr Dorner continued: "We've shown that energy drink consumption has a short-term impact on cardiac contractility
These results indicate that the activation of SERCA and muscarinic receptors may play an important role in the effect of DECC on the cardiac contractility
, heart rate and coronary flow.
Propofol can reduce arterial blood pressure associated with the decreased cardiac contractility
and preload and inhibition of the sympathetic vasoconstrictor activity .
Dobutamine or mid-dosage dopamine (5 - 9 [micro]g/kg/min) can be used as the first line of inotropic support to increase cardiac contractility
in patients with normal BP.