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Related to carcinoma ex pleomorphic adenoma: hemangiopericytoma, Warthin tumor
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These elements are discussed above and include: specifying the number of tumors in cases with multifocality; additional tumor dimensions aside from largest tumor dimension; salivary duct carcinoma variant documentation; distance of carcinoma component from tumor capsule in carcinoma ex pleomorphic adenoma; characterization of location (intratumoral versus extratumoral), degree (focal versus extensive), and size of nerves involved in perineural invasion; and specification of margins involved, closest margins, and distance from closest margins.
Caption: Figure 3: Area of malignant transformation (hematoxylin and eosin stain), carcinoma ex pleomorphic adenoma with the residual chondomyxoid stroma, magnification = 20 x.
In malignant tumors adenoid cystic carcinoma 42% was first commonest tumor and mucoepidermoid carcinoma 39.5% was second than acinic cell carcinoma 7.8% and carcinoma ex pleomorphic adenoma was in 2.6% cases.
Carcinoma ex Pleomorphic Adenoma, Pathologic analysis of 73 cases Hum.
Patients with carcinoma ex pleomorphic adenoma may have a history of a long-standing mass with recent enlargement.
Some of the primary malignant epithelial tumours may arise from a pre-existing BMT through a malignant transformation--the so-called carcinoma ex pleomorphic adenoma (Ca ex PA), pleomorphic adenocarcinoma or malignant mixed tumour (MMT), but most arise de novo.
(10) The most common variant is carcinoma ex pleomorphic adenoma, which is capable of metastasis.
Pleomorphic Adenoma and Carcinoma Ex Pleomorphic Adenoma
Carcinoma ex pleomorphic adenoma and adenoid cystic carcinoma are the most frequently reported salivary malignancies of the PPS.
of Percentage Overall Cases Percentage Mucoepidermoid carcinoma (Low grade) 4 23.54% 8.89% Mucoepidermoid carcinoma (High grade) 3 17.66% 6.67% Acinic cell carcinoma 1 5.88% 2.22% Adenoid cystic carcinoma 2 11.76% 4.44% Carcinoma ex pleomorphic adenoma 2 11.76% 4.44% Undifferentiated 1 5.88% 2.22% Lymphoma's(NHL) 1 5.88% 2.22% Adenocarcinoma 2 11.76% 4.44% Sex Incidence Sex No.
Among malignant tumors, only 2 polymorphous lowgrade adenocarcinomas and 1 salivary duct carcinoma ex pleomorphic adenoma were positive; other tumors were negative.
(11) Some SDCs arise as the malignant component of a carcinoma ex pleomorphic adenoma. Most SDCs show positive distinct membrane staining for HER2/neu protein.