carcinoid

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Related to carcinoid syndrome: Carcinoid tumor
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Words related to carcinoid

a small tumor (benign or malignant) arising from the mucosa of the gastrointestinal tract

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Clinical and echocardiographic comparison of patients with the carcinoid syndrome with and without carcinoid heart disease.
Biopharmaceutical company Lexicon Pharmaceuticals (NasdaqGS:LXRX) reported on Monday the completion of enrollment under its pivotal Phase 3 TELESTAR, clinical trial of telotristat etiprate in patients with carcinoid syndrome.
These stuck-on plaques were thought to be identical to those seen in carcinoid syndrome and ergotamine-induced valvular disease.
The double-blind, randomised, placebo controlled ELECT trial evaluated the efficacy and safety of Somatuline Depot in the treatment of carcinoid syndrome.
The company said elevated serotonin is a hallmark of carcinoid syndrome, and two previous Phase 2 clinical trials have shown that clinical benefits of telotristat etiprate treatment were associated with significant reductions in 5-HIAA, a biomarker of serotonin production.
Carcinoid syndrome is reportedly a chronic condition caused by neuroendocrine tumours that usually originate from the gastrointestinal tract and is characterised by severe diarrhea and flushing episodes with long-term consequences that may include cardiac valve disease.
The encouraging results Lexicon has obtained with its portfolio of serotonin synthesis inhibitors, LX1031 for irritable bowel syndrome, LX1032 for carcinoid syndrome, and LX1033 for other gastrointestinal disorders, informed its decision to reacquire all development and commercialisation rights to these promising drug candidates, said Dr Arthur Sands, Lexicon's president and CEO.
For 30 years, Novartis has supported the NET community with the development of therapeutics in NET and carcinoid syndrome.
Lexicon markets Xermelo (teloristat ethyl) for the treatment of carcinoid syndrome diarrhoea in the United States and has licensed Xermelo to Ipsen Pharma SA for commercialisation in territories outside of the United States and Japan.
The product is intended for the treatment of carcinoid syndrome diarrhoea in combination with somatostatin analogue therapy in adults inadequately controlled by SSA therapy.
Maximum CgA concentrations were detected in patients with NETs of the stomach and lung, and the highest median CgA values were found in patients with tumors of the small intestine, large intestine, and pancreas, particularly in patients with liver metastases and carcinoid syndrome.
Hormone and vasoactive amine secretion from the carcinoid tumour cells cause carcinoid syndrome.
Sandostatin LAR is indicated for acromegaly and severe diarrhea associated with carcinoid syndrome.
2,19) Carcinoid syndrome, present in approximately 10% of carcinoid tumors, can be seen with metastases to the liver, lung, or other sites which venous drainage bypass the portal circulation (e.
In light of progress in the process of regulatory review of telotristat ethyl for carcinoid syndrome, we felt this would be an opportune time to reach a favorable settlement of the remaining financial obligations under our collaboration with Symphony Icon, said Jeffrey L.