The theory that mutagenesis was associated with carcinogenesis
had existed for decades.
However, the mechanism of arsenic carcinogenesis
is still unclear.
People with colon cancer lack sufficient quantities of uroguanylin, and this deficiency is linked with colon carcinogenesis
In the July, 2009 issue of the journal Carcinogenesis
, researchers at Columbia University report the discovery of a protective property for vitamin C against estrogen-induced breast tumors in an estrogen-dependent breast tumor-sensitive strain of rats.
Since arsenic metabolism seems to be a key to the carcinogenic process, sorting out these polymorphisms will be important, but this is extremely difficult to do," says Julian Preston, director of the EPA's Environmental Carcinogenesis
Division and a member of the committee that produced Arsenic in Drinking Water: 2001 Update.
In a recent study in the journal Carcinogenesis
by the Department of Chemical Biology at the Ernest Mario School of Pharmacy, Rutgers University, stilbenes, which are phytochemicals present in grapes and berries, were shown to potentially help prevent colon cancer.
Previous research has shown that environmental factors -- in particular a high-fat, low-fiber diet -- can influence colorectal carcinogenesis
The reduced collagen expression at the early step of carcinogenesis
may cause disturbed keratinocyte adhesion to the basement membrane (Parikka et al.
In research published in part in the December Carcinogenesis
, the compound proved effective in preventing skin and stomach cancers in mice when given in concentrations equivalent to that found in eight hamburgers per day.
Essigmann is particularly interested in the reasons for the differential sensitivity of different species to aflatoxin, as well as the reasons that hepatitis amplifies human risk of aflatoxin carcinogenesis
Effects of indole-3-carbinol and phenethyl isothiocyanate on colon carcinogenesis
induced by azoxymethane in rats.
Inhalation toxicology and carcinogenesis
studies of propylene glycol mono-t-butyl ether in rats and mice.
The present study was conducted to assess the influence of dietary PCC on 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis
Assessing cancer risk is another question, he says, because cadmium carcinogenesis
involves so many unknowns,
The second abstract entitled, "Expression of Multiple Simultaneous Biomarkers in Tissues of Patients with Colitis-Associated Neoplasia", describes preliminary data from a tissue study designed to evaluate the sensitivity of a prototype marker panel targeting alterations involved in ulcerative colitis carcinogenesis