Maintaining a low concentration of calcium within cells is vital to their survival and this is achieved by calcium pumps
on the plasma membrane.
The researchers' starting point was the calcium pump
located in the cell membrane of the model plant thale cress (Arabidopsis thaliana), but the regulatory mechanism also applies to the corresponding calcium pump
in humans and animals.
As the heart ages, these free radicals can greatly alter how well the cellular calcium pumps
on the sarcoplasmic reticulum work.
Certain proteins, such as the calcium pump
protein and the contractile protein myosin, appear to change with age which may account for some alterations in the function of the aging heart.
The key role played by calcium pumps
in controlling of cytoplasmic calcium ions, regulation of calcium pump
activity will have profound effects on calcium signaling (12).
Celladon is developing both biologics and small molecules targeting a key enzyme deficiency in advanced heart failure, the sarcoplasmic reticulum calcium pump
(SERCA2a), which promote contractility but without the negative consequences of current inotropic therapies.
Tenders are invited for Supply of Rabbit Monoclonal (Y124) to PKC alpha Mouse Monoclonal (5F 10) to calcium pump
pan PMCAAT Pase
The small amount of calcium released per stimulus is the key element that permits the calcium pumps
in midshipman swimbladder muscle to keep up over long periods of high-frequency stimulation," Rome explained in the report.
Furthermore, memory formation and retrieval were amended both by calcium chelation as a therapy and by pharmaceutical inhibition of internal calcium pumps
Samuel Denmeade at Johns Hopkins University in Baltimore, Maryland, and colleagues have spent 15 years engineering an analogue of thapsigargin, the plant's active ingredient, which works by shutting down essential calcium pumps
Furthermore, impairments in the calcium sequestration and extrusion pumps of either the ER (SERCA pumps) or the plasma membrane energy-dependent calcium pumps
(PMCA) have reduced activity in aged neurons.
Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps
European, American, and Australian researchers in a number of medical specialties, prominently pharmacology, discuss such aspects as fluorescent indicators, genetically encoded fluorescent calcium indicator proteins, calcium signaling networks in yeast, methods for studying calcium pumps
, apoptosis, and calcium entry channels and drug discovery.