In their study paper, Prisby and colleagues explain that the processes of vascular calcification
"The interesting thing here is that, in order for MGP to inhibit calcification
, it needs to be gamma-carboxylated by vitamin K.
The spinal computed tomography scan (CT scan) and magnetic resonance imaging (MRI) revealed the calcification
within IVD associated with huge calcified disc herniation at T5/6 (black arrows in figure 1 and 2).
CT chest showed right-side pleural effusion with underlying lung calcification
, including that observed at the age over 60 years and on head CT showing punctate calcification
in the basal ganglia, was not calculated.
In an effort to identify risk factors for hippocampal calcifications
and investigate the association between hippocampal calcifications
and cognitive function, Esther J.M.
INZ-701 is an enzyme replacement therapy under development with the intention to be used for the treatment of calcification
disorders of the circulatory system, bones, and kidneys.
Potential Pathogenesis of Advanced Vascular Calcification
However, nodular calcification
was also suspected, as there were calcifications
around the lesion.
is a complex, irreversible biological process, which involves differentiation of vascular smooth muscle cells (VSMCs) into chondrocyte- or osteoblast-like cells (chondrogenesis or osteogenesis).
In addition, we recently showed CD137 signaling contributed to the calcification
of atherosclerotic lesions .
The firm will use the proceeds from this financing to advance its lead enzyme replacement therapy for the treatment of Generalised Arterial Calcification
of Infancy (GACI) and Autosomal Recessive Hypophosphatemic Rickets Type 2 (ARHR2) into the clinic.
A less understood cause of arterial stiffening is calcification
Researchers also found that increased dietary potassium levels lessened vascular calcification
and aortic stiffness.
But a diet high in potassiumrich foods - such as broccoli, parsnips and brussels sprouts, pulses, nuts and seeds, fish, beef and poultry - alleviates vascular calcification