Realizing that bulk laxatives
, such as psyllium (Metamucil), or increased food fiber intake in the diet are acceptable if sufficient water intake is assured.
Clinical evaluation of methylcellulose as a bulk laxative
. Dig Dis Sci.
There is little evidence to suggest that bulk laxatives
are more advantageous than other classes of laxatives (13,14); however, because of their safety and other possible health benefits, it is reasonable to start treatment of chronic constipation with a bulk laxative
Psyllium, which is a major source of fiber, is an effective bulk laxative
. It's also good for gastrointestinal irritations.
The new products are: an antidiarrheal formulated with loperamide HCl (the active ingredient in Johnson & Johnson's Imodium), an antigas version with simethicone as the active ingredient, and the company's first bulk laxative
. SmithKline, which besides producing H-2 blockers is also heavily into the O-T-C antacid business with Tums, Citrucel and Gaviscon, says that the high calcium
Despite the fact that many industry observers see the bulk laxative
business as having already peaked, at least one company debuted a fiber-based product in
: This class of laxative includes natural fibres (psyllium) and semisynthetic fibres such as methylcellulose.
These include antacids that contain aluminum or magnesium (Maalox, Mylanta); some cholesterol-lowering drugs, including cholestyramine (Questran) and colestipol (Colestid); the heartburn drug metoclopramide (Reglan); sulfasalazine (Azulfidine), which is used to treat ulcerative colitis and rheumatoid arthritis; and bulk laxatives
(such as psyllium, Metamucil or Citrucel).
(2002) study, the authors were unable to quantitatively assess the tolerability of laxatives; however, side effects such as abdominal distension from bran, bloating, gas production and increased fluid requirements for bulk laxatives
, urgency, cramps and flatulence from senna fibre combinations were alleged.
The common agents prescribed include bulk laxatives
, osmotic laxatives and stimulant or contact laxatives.