These changes were accompanied with disrupted brush borders
and inclusion bodies in cytoplasm of tubular cells on PAS stained sections.
Some tubules also showed areas of patchy necrosis with loss of brush border
and vacuolation implying thereby that tubular injury was not in fact fully reversed (Fig-2).
KEY WORDS: AY2-microglobulin Ligustrazine Neonatal scleredema Renal brush border
membrane enzyme Renal injury.
The activity of the enzymes maltase, sucrase, alkaline phosphatase and phytase, all integral catalytic proteins of the intestinal brush border
, determined in the duodenal segment, increased in the first 72 hrs.
Postnatal ontogeny of kinetics of porcine jejunal brush border
membrane-bound alkaline phosphatase, aminopeptidase N and sucrase activities.
Anchoring and biosynthesis of stalked brush border
membrane proteins: glycosidase and peptidase of enterocytes and renal tubuli.
PAS stain showed an enlarged intracytoplasmic band with PAS positive granules in the apical pole of enterocytes in contrast to the thin uniform linear staining of the brush border
in the normal mucosa (Figs.
Histopathological changes in kidney of diabetic rat showed signs of tubular necrosis with loss of their brush border
, vacuolar degeneration of proximal tubules and thickened basement membrane.
1), (3) Mature absorptive intestinal cells with a brush border
Na/H- and Cl/OH- exchange in rat jejunal and rat proximal tubular brush border
Subsequently the toxins insert into the membrane and form non-specific pores or ion channels, causing loss of homeostasis across the brush border
membrane leading to gross structural changes in the midgut and eventually death of the larvae (Arnold et al.
By contrast, amino acid absorption is dependent on a gradient of sodium ions across the brush border
membrane of the intestinal epithelial cells.
The brush border
of the intestinal mucosa acts as the absorption gate.
Caveolae in the apical cytoplasmic membrane, as well as coated pits and mainly transparent vesicles, multivesicular bodies and lysosomes occurred in the apical cytoplasm of principal cells close related to the apical brush border
(microvilli), allowing support to characterize a process of endocytosis (Figs 5 and 6).
with water, lay second pastry disc over base and filling, press edges firmly together to seal.