Rituals can kill--A fatal case of brucine
Yang, "Preparation, characterization and tissue distribution of brucine
stealth liposomes with different lipid composition," Pharmaceutical Development and Technology, vol.
(molecular formula: [C.sub.23][H.sub.26][N.sub.2][O.sub.4]) was purchased from the National Institute for Food and Drug Control (lot number 110706-201306; purity: 91.7%).
Modern research shows that the main active ingredient is alkaloids, the content of about 5% of crude drugs, mainly brucine
, strychnine and its nitrogen oxides, of which brucine
Incidentally, the spell checker on my computer has a lot of fun with Welsh: brecwast came up as 'precast', brecinio as 'brucine
' (poisonous substance derived from seeds) and brinio as 'briny' (clearly my computer pictures me as some sort of salty old sea dog).
The toxic principles include strychnine and brucine
extracted from seeds as a colorless, odorless, bitter material.
, an effective natural compound derived from nux-vomica, induces G1 phase arrest and apoptosis in LoVo cells.
The application of a series of chromatographic techniques (HPLC-DAD, LC-MS/MS, and GC-MS) led to the successful detection of antioxidant purine alkaloids (caffeine, theobromine, and theophylline) and indole alkaloids (harmine, harmane, harmol, yohimbine, brucine
, and strychnine) in Andrographis paniculata and in dietary supplements containing this plant.
N[O.sub.2]--N and N[O.sub.3.sup.-]-N were analysed by alfa-naftilamina methods and by brucine
methods, respectively (APHA, 2005).
A solution of 4 (100 mg, 0.24 mmol), brucine
(95 mg, 0.24 mmol), and boric acid (30 mg, 0.48 mmol) in 10 mL of methanol was stirred for 72 h at room temperature.
Nitrate was determined by brucine
sulfate to give yellow color at 410nm.
Many nitrogen containing compounds including quinoline, aniline, brucine
, and strychnine have shown good corrosion inhibition for zinc in acidic medium.
nux vomica, 80% of which are strychnine and brucine
, as well as their derivatives such as brucine
N-oxide or isostrychnine (Cai et al., 1990).
This was particularly true in cases of poisoning when alkaloids such as morphine, strychnine, and brucine
Various plant alkaloids such as cinchonamine, quinine, strychnine, brucine
, papaverine, narcotine, nicotine, and purines such as caffeine and theophylline were early shown to have varying degrees of mitoclastic effect.