Key words: Adaptive immunity, Autophagy, Brucella spp, Innate immunity, Intracellular survival, Mechanism of evasion from host, Virulence factors.
Brucellosis is a zoonotic, contagious bacterial disease of livestock, caused by facultative intracellular Gram-negative, non-spore forming, coccobacillus of the genus Brucella which live in a microaerophilic environment inside its host.
The previous reviews of Brucella had described only the evading mechanisms of Brucella spp.
In vitro stimulation of splenocytes from mice immunized with pV273-sod or pV278-sod vaccines with 2 [micro]g/ml of crude Brucella proteins (CBPs) significantly increased their cellular proliferation (P < 0.05).
This response can be induced by immunization, allowing its rapid activation at the time of infection with Brucella, where its immunogenic antigens are processed and presented to T cells .
IgG2a is produced by plasma cells in the presence of IFN-[gamma] , a cytokine associated with an efficient protection against intracellular pathogens, such as Brucella .