In a study of monodisperse albuterol aerosols (1.5, 3.0, and 6.0 [micro]m) in patients with asthma, improved bronchodilation
was achieved with larger particles that resulted in lower lung doses compared with an equivalent dose of smaller particles .
Busse et al., "Lung function in adults with stable but severe asthma: Air trapping and incomplete reversal of obstruction with bronchodilation
," Journal of Applied Physiology, vol.
Current drug therapy for stable COPD focuses primarily on bronchodilation
through inhaled beta2-agonists and anticholinergic agents, immunisation, and elimination of smoking as a risk factor.
For acute episodes of short-acting bronchodilators, systemic corticosteroids, and ipratropium are used to induce rapid bronchodilation
and reduce spasm.
witlI once-daily dosing of tiotropium (Spiriva) in stable chrenic obstructive pulmonary disease.
A significant increase in these values has occurred following bronchodilation
. Good bronchodilator reversibility bronchodilator response (BDR) is indicated by postbronchodilator increase in FEV1 by 200 mL or >12%.
Long-acting agents, such as salmeterol, formoterol, and arformoterol are indicated for maintenance bronchodilation
and control of bronchospasm, and for control of nocturnal symptoms in asthma or other obstructive diseases.
 Meraz E, Nazeran H, Goldman M, Diong B: Respiratory System Model Parameters Track Changes in Lung Function after Bronchodilation
. In proceedings of the 25th Southern Biomedical Engineering Conference, Miami, Florida.
with QVA149 versus single bronchodilator therapy: The SHINE study.
The dual bronchodilation
provided by indacaterol/glycopyrronium is delivered through our patented Breezhaler device, a single-dose dry powder inhaler with low-airflow resistance, making it suitable for patients with different severity of airflow limitation.
For the primary outcome parameters (relative change of [FEV.sub.1] and [MEF.sub.75-25] before bronchodilation
) no treatment effect could be detected in the cross-over analysis ([FEV.sub.1], p = 0.6763 and [MEF.sub.75-25] p = 0.6953).
Non-selective beta-blockers may exacerbate respiratory conditions such as asthma, emphysema and chronic obstructive pulmonary disease (COPD) due to systemic absorption and subsequent respiratory ([[beta].sub.2]) receptor blockage (preventing resultant bronchodilation
It has been suggested that inhaled salbutamol may result in a performance improvement by causing a significant bronchodilation
in the airways of non-asthmatics leading to an improved [V.sub.E] and increased oxygen uptake during exercise.
Overlap can be diagnosed by one major criterion and two of the following: response to bronchodilation
at least two separate times (>12% and >200 mL in FE[V.sub.1]), history of atopy, and increased total serum IgE.