All these diseases lack large clusters and nodules of Langerhans cells even though they might show a variable number of scattered Langerhans cells in the interstitium and the bronchiolar
The ex vivo bronchiolar
smooth muscle contraction causes prominent narrowing of the bronchiolar
lumen, which may give a false impression of constrictive bronchiolitis or other small airway diseases, including asthma.
Virus antigen expression was seen in many type II pneumocytes, few type I pneumocytes, alveolar macrophages, bronchiolar
ciliated and nonciliated epithelial cells, and rare bronchial ciliated epithelial cells.
For example, the pandemic human strains of 1918, 1957, and 1968, on the one hand, and the recent subtype H5N1 strains, on the other, show different tropisms: panepithelial for the former strains (20,27,28) and limited to the bronchiolar
and alveolar epithelia for the latter strains, a result compatible with our own observations on mouse-adapted viruses.
Churg and associates (9) reported a cohort of 12 patients with a novel form of ILD characterized pathologically by small airway-centered interstitial fibrosis (ACIF) and meta plastic bronchiolar
epithelia extending around and often linking fibrotic and sometimes heavily muscularized bronchioles (Figures 1 and 2).
or alveolar cell carcinoma of lung: a case report.
Signs of regeneration in bronchiolar
and alveolar epithelia were observed both in foxes infected intratracheally and in those fed infected bird carcasses.
Consistent with histologic observation of lung lesions, large amounts of avian influenza virus binding receptor (SA[alpha] 2,3-gal) were identified in canine tracheal, bronchial, and bronchiolar
epithelial cells, which suggests potential for direct transmission of avian influenza virus (H3N2) from poultry to dogs.
3]-tolerant rats produced significantly higher levels of cysteinyl-leukotrienes in bronchiolar
lavage fluid even when compared to a 50-mg/kg dose of 1-NN in rats exposed to filtered air.
Usual interstitial pneumonia: at low magnification, a patchwork pattern of honeycomb change with bronchiolar
metaplasia associated with zones of normal lung and lung with interstitial inflammation was observed (hematoxylin-eosin, original magnification X40).
Immunohistochemical staining, with a polyclonal antibody (6), showed morbillivirus antigen in bronchiolar
epithelium, syncytial cells, monocyte-like cells, and cell debris of affected lymph nodes and brain; these tissues often showed a positive intracytoplasmic globular or granular immunoreaction.
The epidemiologic implications of these findings are important for children residing in polluted environments, because bronchiolar
disease could lead to chronic pulmonary disease later in life.
37,38) Although data on patients without such transplants are limited, the authors routinely look for bronchiolar
findings that might suggest this possibility.
alkylation and necrosis by 3-methylfuran, a naturally occurring potential atmospheric contaminant.
Similarly, we did not find viral antigen in bronchiolar
epithelium in the lung sections.