During the additional year of follow-up, 22 of the 203 patients in whom asthma had been ruled out had a positive bronchial challenge
test result at 6 or 12 months.
Heyder, "Impulse oscillometry in healthy nonsmokers and asymptomatic smokers: effects of bronchial challenge
with methacholine," Journal of Aerosol Medicine, vol.
Investigation of cough Clinical investigations Indication Chest X-ray (CXR) All chronic cough or if suspect pneumonia/cancer Sputum M, C and S or acid-fast If purulent sputum produced bacilli staining and TB culture Pulmonary function tests (pre-and If suspect asthma or chronic post-bronchodilator spirometry, obstructive pulmonary disease serial peak flows) (COPD) Bronchial challenge
tests If suspect asthma (metacholine, exercise) Gastrointestinal tests If suspect GORD (24-h oesophageal pH) Bronchoscopy If suspect cancer, foreign body or sputum -ve TB High-resolution computed If suspect bronchiectasis or ILD tomography (HRCT) Electrocardiogram (ECG) and If suspect cardiac disease echocardiography
Forced expiratory volume in 1 sec (FE[V.sub.1]) and PEF were measured with a portable combined spirometer every 15 min during the exposure to formaldehyde or air-only in the chamber and every hour until the methacholine provocation test, which was performed 8 hr after the end of the allergen bronchial challenge
Chief among these is bronchial challenge
testing, a topic covered well and in sufficient detail to guide a lab in establishing this additional testing protocol if they are not already doing it.
Exclusion criteria for methacholine challenge were history of ischaemic heart disease and use of medications influencing the outcome of bronchial challenge
(oral steroids, anticholinergic drugs and oral or topical [Beta]-blockers).
Delayed asthmatic response to bronchial challenge
with allergen-mediators, eicosanoids, eosinophil and neutrophil constituents in the blood and urine (abstract).
(15.) Fish JE, Peters SIR Bronchial challenge