Unlike other diseases, a single breakthrough seizure
due to change in delivered medication dose can have devastating consequences, including loss of driver's license, injury, and even death," the paper said, adding that generic substitutions should never be made without the attending physician's approval.
In cases such as epilepsy where the product's dose is so carefully defined, this random switching can mean the difference between freedom from seizures and a potentially devastating breakthrough seizure
Many epilepsy patients can get complacent about their care and often believe that it's alright to have a breakthrough seizure
every now and then, " says Dr.
Successful Therapy: The status epilepticus was completely terminated by the therapy, without breakthrough seizures
, or discontinuation due to side-effects, or death during the therapy.
The most common reasons for breakthrough seizures
reported by the patients were sleep deprivation, stress, alcohol, non-compliance and menses.
Unfortunately, a significant percentage of individuals with IDD are medically refractory and despite multiple trials of at least three different AED's, many still have breakthrough seizures
The combination of alcohol consumption, sleep deprivation (as alcohol consumption is often associated with evening social events), and missed medication can lower seizure threshold and place the adolescent at risk for breakthrough seizures
Seizure safety in either of these populations is paramount; however, those children who undergo surgical evaluation due to persistent breakthrough seizures
on anti-epileptic medication are already at an increased risk for seizures, which only increases further upon admission to the hospital given their rapid medication taper.