The world No 1 pounced on the first show of weakness from his 18-year-old opponent - by five days the second youngest player in the draw - two unforced errors in the sixth game allowing him to break serve
with a superb backhand passing shot.
With the duel locked at 3-3, the home favourite passed up a golden chance to break serve
and allowed Djokovic to hit back from 0-40 to hold.
Rusedski, though, lost his rhythm in the third set, allowing the Frenchman to break serve
twice and race into a two-setsto-one lead in the match by winning the set 6-1.
Agassi briefly threatened to break serve
and take the set in the 12th game when he reached 0-30 on Philippoussis' serve, but the man nicknamed `Scud' hammered down three aces to force a tie-break.
Radek had to receive treatment on his elbow midway through the fourth set but both players only managed to break serve
once in three hours and 34 minutes.
But a run of four straight games put Murray in a degree of trouble, and he had to break serve
to force the tie-break.