Jurors have also heard about "second impact syndrome", where a recent previous trauma can lead to brain swelling
on a second blow.
Pathologist Dr James Sunter said the brain swelling
was caused by "blunt force injury" to the head, the jury was told.
It was "unfortunate", however, that the link between the change in behaviour and the brain swelling
was not made sooner.
Biogen announced the enrollment of the first patient in the global Phase 3 clinical study CHARM, designed to evaluate BIIB093 for the prevention and treatment of severe cerebral edema in large hemispheric infarction, or LHI, one of the most severe types of ischemic stroke where brain swelling
often leads to high morbidity and mortality.
Health authorities issued a nationwide warning for Japanese encephalitis _ brain swelling
caused by a mosquito-borne viral infection _ after they confirmed the presence of a mosquito vector here.
But it comes with a big downside: It can cause serious side effects, including high fevers and sharp drops in blood pressure as well as potentially fatal brain swelling
LHI is a severe form of ischemic stroke, where brain swelling
(cerebral oedema) often leads to a disproportionately large share of stroke-related morbidity and mortality.
In pre-clinical studies, Cirara has been shown to block SUR1-TRPM4 channels that mediate stroke-related brain swelling
"It's not conceivable that the bleeding and brain swelling
could have occurred without catastrophic brain dysfunction," Dr Lammie said.
Mr Tunney, 24, suffered a severe head injury with brain swelling
and bleeding, fell into a coma and died in hospital weeks later on July 29, the court heard.
There was recent bruising which was consistent with "forcible gripping", brain swelling
, brain bleeding and severe and widespread retinal bleeding.
Worldwide STBI is a common neurosurgical problem which can cause massive brain swelling
leading to uncontrolled raised intracranial pressure (ICP), resulting in severe brain damage or even death.
Baig says that aggressively blunting the immune response, and the brain swelling
that goes with it, might help more patients survive.
The combination of brain swelling
and SFC may be the cause of the rapid aggravation of the patient's condition.