Compared with the furosemide serum binding at a low molar ratio of oleate to albumin (comparable with that observed in resting healthy subjects), the binding of furosemide to serum protein was inhibited when four or more oleate molecules were bound to
one albumin molecule.
After nine sickle-cell patients breathed a mixture of air and nitric oxide gas for 45 minutes and then gave blood samples, their abnormal hemoglobin bound to
oxygen almost as tightly as normal hemoglobin does, the team first reported in the September 1997 JOURNAL OF CLINICAL INVESTIGATION (SN: 9/20/97, p.
To screen environmental pollutants for possible interactions with ER, we measured displacement by xenobiotics of [[sup.3]H]-[E.sub.2] bound to
ER in MCF-7 cells growing in monolayer culture.
Most previous X-ray crystallography of polymerases bound to
DNA showed the enzyme's hand in a relatively open configuration that made it difficult to understand how the polymerase could work.
They found that the modified form of GroEL bound to
ATP as well as the normal version did.
Ironically, even androgen mimics that are devoid of estrogen activity might feminize a male animal if they bound to
an androgen receptor-and thus shut out natural androgens-yet failed to turn it on (SN: 1/22/94, p.
They determined the nucleotide sequences of the 39 kinds of RNA molecules that had bound to
Researchers at GSI have also observed for the first time an extremely unusual type of radioactive decay in which the electron (beta particle) produced by the decay of a "parent" nucleus stays bound to
the newly created "daughter" nucleus instead of speeding off.
That advance was the ability to produce MHC-I molecules bound to
identical peptides in sufficient quantity for X-ray studies.
But oddly, Kramer's team found that cells with the first, less metastatic integrin bound to
laminin more tightly than those with the second, more metastatic integrin.