Examination of the bone marrow is one of the diagnostic pillars of haematological practice.
Bone marrow aspiration and trephine biopsy complement each other and in many centers both the specimens are obtained at the same time and from the same site1, 11.
All the cases of lymphoma were diagnosed on trephine biopsy but the lymphoma cells were observed only in 04 out of 18 (22.2%) cases on bone marrow aspirate smear.
In our study 100 % case (03/03) of Granulomatous inflammation in the bone marrow were diagnosed on trephine biopsy and none of the case was diagnosed on bone marrow aspirate.
All the cases of Myelofibrosis (07/07) were diagnosed on trephine biopsy and the bone marrow aspirate was unsuccessful in all cases due to marked fibrosis.
Bone marrow biopsy remained the gold standard for diagnosing Aplastic Anaemia.
Bone marrow aspiration and trephine bone biopsy complement each for bone marrow evaluation.
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Bilateral trephine bone marrow biopsies in lymphoma and other neoplastic disease.
The bone marrow aspirate and biopsy in the diagnosis of unsuspected hematologic malignancy: a clinical study of 19 cases.
Comparative utility of diagnostic bone marrow components: a 10-year study.
ICSH guidelines for the standardization of bone marrow specimens and reports.
Performing bone marrow aspiration and biopsy in children: recommended guidelines.
Comparative evaluation of simultaneous bone marrow aspiration and bone marrow biopsy: an institutional experience.
Early reconstitution of haematopoiesis after allogeneic bone marrow transplantation: a prospective histopathological study of bone marrow specimens.