The lesional cells are typically fibroblast-like (Figure 7, B) and can be mistaken for a benign spindle cell lesion (eg, scar, neurofibroma, dermatofibroma), a conventional blue nevus
, or desmoplastic forms of nevi.
On the other hand, the face-to-face diagnoses consisted of pigmented basal cell carcinoma (4), intradermal nevus (6), seborrheic keratosis (4), benign melanocytic lesion (14), blue nevus
(3), exogenous pigmentation atypical nevus (2), dermatofibroma (1), congenital nevus (1), solar lentigo (2), and melanoma (3).
Final pathology demonstrated blue nevus
in one out of six cores on the right and two out of six cores on the left.
Images in the Benvenuto-Andrade study show that pink coloration becomes redder in some non contact polarized dermoscopy images and appears in some benign images, creating a false-positive pink rim sign, such as what was seen in a dysplastic nevus and a blue nevus
in that study .
Lesions included adnexal neoplasm, ameloblastic fibro-odontoma, basal cell carcinoma, benign fibrous histiocytoma, blue nevus
, chondrosarcoma, compound nevus, epithelioma adenoides cysticum, esthesioneuroblastoma, Ewing sarcoma, fibrosarcoma, giant cell granuloma, granulocytic sarcoma, hemangioma, hemangiopericytoma, Langerhans cell histiocytosis, lymphangioma, lymphoma, melanoma, neuroblastoma, neurofibroma, ossifying osteofibroma, osteochondroma, osteosarcoma, port wine stain, rhabdomyosarcoma, Spitz nevus, and xanthogranuloma.
The features of NCH overlap with blue nevus
both clinically and histopathologically.
Certain lesions are said to be precursor lesions of melanoma, including the common acquired nevus, dysplastic nevus, congenital nevus and cellular blue nevus
On the other hand, ZEMBOWICZ & MIHM (2004) considers that most of the histological variants recently introduced in the medical literature such as amelanotic/hypomelanotic blue naevus, amelanotic cellular blue naevus, epithelioid blue nevus
, compound blue naevus, atypical blue naevus, pilar neurocristic hamartoma, blue naevus-like metastatic melanoma, pigmented epithelioid melanocytoma and cutaneous neurocristic harmatoma/ malignant neurocristic tumors could be classified as traditional categories of dendritic melanocytic proliferations.
Some entities that can mimic melanoma include a halo nevus, solar lentigo, traumatized blue nevus
, seborrheic keratosis, pigmented basal cell carcinoma, pigmented Bowen's disease, pigmented squamous cell carcinoma, and thrombosed angioma.
The differential diagnosis for malignant melanoma includes seborrheic keratosis, traumatized or irritated nevus, pigmented basal cell carcinoma, lentigo, blue nevus
, angiokeratoma, traumatic hematoma, venous lake, hemangioma, dermatofibroma, and pigmented actinic keratosis.
Molecular analysis of a case of nevus of Ota showing progressive evolution to melanoma with intermediate stages resembling cellular blue nevus
. Am J Dermatopathol.
It is usually a pigmented lesion, sometimes a neuroid nevus, a blue nevus
, a neurofibroma, or a primary or secondary malignant melanoma, surrounded by a halo of depigmented zone.
However, single lesion frequency of reactive perforating collagenosis (RPC), blue nevus
, atrophic skin lesions, cafe-au-lait macules, melasma, macular amyloidosis, pigmented verruca vulgaris, lentigo maligna melanoma, dermatofibroma and pigmented basal cell carcinoma (BCC) was also seen, not mentioned in table.
Histopathologically, three patterns may be encountered: A compound or an intra-dermal nevus, a neural nevus, and a blue nevus