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Methods for siRNA delivery across the blood-brain and blood-retina barrier are also covered for therapeutic and diagnostic use.
The blood-retina barrier normally prevents molecules in the blood from reaching the retina.
ECT enables the controlled, continuous delivery of therapeutic factors directly to the retina, thereby bypassing the blood-retina barrier.
Furthermore, RXi received a notice of allowance from the Japanese Patent Office for the delivery of double stranded siRNAs (21 to 23 nucleotides in length) across the blood-retina barrier.
It has been shown to cross the blood-brain and blood-retina barriers, meaning it can positively impact brain, central nervous system, retinal and optic nerve systems for improved protection from light induced oxidative degradation and thus improved eye health.