We can see the formation of tiny bubbles, watch the interaction with the blood-brain barrier
model and determine what kind of damage or leakage might occur.
This work for drug researchers reports on current research on central nervous system (CNS) drugs that can cross the blood-brain barrier
, highlighting research from industry and academia around the world.
21 Neuron show direct evidence that aging influences the breakdown of the blood-brain barrier
and that accelerated deterioration could contribute to learning and memory problems later in life.
The rats without blood-brain barrier
and memory impairment also ate less of the high-energy diet than did our impaired rats," Davidson said.
However, little has been known about how the blood-brain barrier
maintains its integrity as the brain it protects develops.
The blood-brain barrier
is a semipermeable molecular "wall" that controls the passage of substances from the bloodstream into the brain.
But the only effect by type of antihypertensive that the patient was exposed to was a slightly higher risk in those who took an ACE inhibitor that did not cross the blood-brain barrier
, with about an 18% higher risk than that seen in the patients treated with other antihypertensives.
In its neuroprotective role, the blood-brain barrier
(BBB) functions to hinder the delivery of many potentially important diagnostic and therapeutic agents to the brain.
They can block activated T cells from breaching the blood-brain barrier
Once we understand how West Nile virus affects the pathways that control the tight junctions of the blood-brain barrier
, it may be possible to design drugs that prevent infection of the brain.
One limitation of any proposed cell culture system or invertebrate model for developmental neurotoxicity is that the fetal mammalian brain is typically protected by diffusion barriers: the placenta (Sastry 1991) and, depending on the stage of development, the blood-brain barrier
(Saunders and Mollgard 1984).
MS involves an inappropriate activation of immune-system cells, which enables them to leave the blood stream, breach a protective layer called the blood-brain barrier
, enter the central nervous system, and initiate attacks on myelin, the fatty protein layer that normally protects and insulates nerve fibers, or axons.
SEATTLE -- Impel NeuroPharma today announced a set of important milestones that accelerate its progress in enabling small molecules and biologics to bypass the blood-brain barrier
This study was made in a genetically-modified cell model of the blood-brain barrier
that contains high levels of the transporter P-glycoprotein.
On the other hand, aerosolized particles that circumvent the blood-brain barrier
might someday serve as delivery vehicles for drugs.