Accordingly, it is my sincere hope that researchers and clinicians reading this article will question their patients with respect to a history of both remote and recent neck injuries, then study their patients' cervical spine CT images and palpate to identify areas of inflammation (especially those that point to the presence of a blood-CSF barrier
Analysis of total protein in the CSF may show normal results despite a blood-CSF barrier
dysfunction, because it does not take into account the serum protein level .
To a certain degree, CSF is shielded from nonneurologic protein sources by the blood-CSF barrier
and has a relatively slow protein turnover.
Because small amounts of immunoglobulins typically enter the cerebrospinal fluid (CSF) by passive transfer across the blood-CSF barrier
, differentiation of the origin of immunoglobulins in CSF is needed before intrathecal immunoglobulin synthesis can be diagnosed (2).
As a mirror of blood-CSF barrier
status, the CSF/serum albumin ratio was calculated; its threshold of positivity varied between 6 x [10.sup.-3] and 8 x [10.sup.-3] with the age of the patients.
Measurement of total protein in cerebrospinal fluid (CSF) is used mainly to detect various central nervous system (CNS) diseases associated with either increased permeability of the blood-CSF barrier
or increased intrathecal immunoglobulin synthesis.
Serum-CSF protein gradients, the blood-CSF barrier
and the local immune response.
The goal of this Program Announcement with set-aside funds (PAS) is to invite applications for studying the neurobiological and cerebrovascular mechanisms through which the neuroprotective blood-brain and blood-csf barriers
function in the healthy and diseased adult, aged and pediatric brain.