By now, it is common knowledge among researchers that ABC transporters play a key role in the function of the blood-brain barrier (BBB), blood-CSF barrier
, blood-testis barrier, intestinal epithelia (absorption), airway epithelia, liver epithelia and the kidney epithelia," explained Gabor Heltovics, SOLVO's business development director.
These findings indicate that both the ST1 and ST104 strains cause bacteremia and sepsis but that the ST1 strains are more likely to cross the blood-CSF barrier
and subsequently result in meningitis.
Unfortunately, the author still focuses on the older models of blood-CSF barrier
function ("serum leak"), while struggling with the models derived from current understanding of biophysics and protein dynamics.
We included only CSF samples showing no or only minor contamination with erythrocytes (<150/[micro]L), no intrathecal humoral or cellular immune response, and normal or only slightly disturbed blood-CSF barrier
as measured by albumin quotient.
To a certain degree, CSF is shielded from nonneurologic protein sources by the blood-CSF barrier
and has a relatively slow protein turnover.
Because small amounts of immunoglobulins typically enter the cerebrospinal fluid (CSF) by passive transfer across the blood-CSF barrier
, differentiation of the origin of immunoglobulins in CSF is needed before intrathecal immunoglobulin synthesis can be diagnosed (2).