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and his colleagues were the first to show that tumor cells secreted VPF and that a blocking antibody to VPF could prevent the devastating edema and fluid accumulation characteristic of ovarian, breast, and many other human cancers.
The results of a new study show that treatment with an anti-C5 complement blocking antibody significantly reduced the bronchial inflammation and airway constriction that prompts asthma's hallmark symptoms -- shortness of breath, chest tightness and wheezing.
Preclinical data suggest that a blocking antibody to HMGB1 may provide protection in chronic diseases, such as rheumatoid arthritis, and in acute life-threatening conditions, such as sepsis.
The results suggest that systemic administration of an IL-9 blocking antibody may provide significant clinical benefit in preventing or treating asthma.
Mice were given weekly injections of a blocking antibody to myostatin over a three-month period.
VEGF-A or VEGF-B stimulation of VEGFR-1+ colon tumor cells led to VEGFR-1 activation and signaling, and induction of cancer cell motility and invasion, which could be inhibited by treatment with a blocking antibody to VEGFR-1 (IMC-18F1).
Nasdaq: MAGN) today announced the receipt from the United States Trade and Patent Office of a patent covering the use and administration of a blocking antibody to interleukin-9 (IL9), the Company's proprietary product, for the treatment of asthma and bronchial hyperresponsiveness.