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These data showed that in SW620 cells, Pcy was able to activate the Fas-receptor after blocking TRAIL-death receptors, explaining, therefore, the enhanced apoptosis observed when SW620 cells were exposed to the DR4/DR5 blocking antibody.
The novel type of VEGFR-3 blocking antibody has an unprecedented mechanism of action, which was effective even at very high concentrations of the VEGF-C growth factor.
It is also the sole GS component with a single-pass transmembrane domain and a large extracellular segment [38] that is potentially targetable with a blocking antibody.
He says the onset of arthritis took two weeks longer in the receptor-antibody-treated mice than in mice not given the blocking antibody.
Findings from AVEO's work on the FGFR pathway, which strongly support the belief that FGFR2 plays an essential role in the initiation and/or maintenance of human cancers harboring FGFR2 amplification, were highlighted in a poster presentation earlier this week titled, "Essential role of fibroblast growth factor receptor 2 (FGFR2) in tumorigenesis of human cancers harboring FGFR2 amplification demonstrated by a functional blocking antibody.
Hoffmann-La Roche Ltd (Roche) under which Roche has agreed to supply its PD-L1 blocking antibody Tecentriq (atezolizumab) for a clinical study combining Bavarian Nordic's cancer vaccine, CV301, and Tecentriq in patients with urothelial carcinoma, or bladder cancer.