And it might have been easy to overlook this intriguing outcome from the title of the resulting 2011 paper, "Mechanosynthesis of the metallodrug bismuth subsalicylate
can be helpful as an antidiarrheal agent, (35) but is not often recommended because the regimen makes adherence difficult and because antibiotics and loperamide are effective.
, the active ingredient in Pepto-Bismol, can also work.
Among the options available are traditional antacids, H2 blockers, products formulated with bismuth subsalicylate
, proton pump inhibitors and combination medicines.
Methods: Patients were randomized to a 2-week course of either bismuth subsalicylate
, metronidazole, tetracycline, and cimetidine or lansoprazole, amoxicillin, and clarithromycin.
For example, bismuth subsalicylate
(Pepto-Bismol), which contains salicylate, may lead to increased side effects when taken with other salicylates, like aspirin.
An alternate quadruple regimen includes bismuth subsalicylate
, tetacycline, metronidazole, and a PPI or a H2-receptor blocker for 2 weeks.
Another remedy: Pepto-Bismol or some other brand of bismuth subsalicylate
She subsequently experienced malaise, anorexia, and feverishness, and she occasionally took one bismuth subsalicylate
In the past, people planning to visit foreign destinations were advised to prevent "traveler's diarrhea" by taking bismuth subsalicylate
Studies show a decrease in the incidence of TD with use of bismuth subsalicylate
and with use of antimicrobial chemoprophylaxis.
Adults are treated with "triple therapy" - bismuth subsalicylate
(Pepto-Bismol), metronidazole and amoxicillin.
has both a protective effect and an antibacterial effect against H.
It was susceptible to bismuth subsalicylate
, bismuth subcitrate and furazolidone but not to anti-ulcer agents (cimetidine, ranitidine, misoprostol and sucralfate), NSAIDs or oral penicillin.
Available data are not extensive enough to exclude a risk to the traveler from the use of such large doses of bismuth subsalicylate
over a period of several weeks.