The company has exclusive worldwide rights to a portfolio of five therapeutic programs in clinical trials or preclinical studies, and is also developing novel and selective agonists of the thyroid beta receptor
for GSD Ia, and X-linked adrenoleukodystrophy, as well as two earlier-stage programs targeting metabolic diseases and anemia.
VK0214 is a novel, orally available small molecule thyroid receptor agonist that possesses selectivity for the beta receptor
The mechanism of the effect on potassium is probably activation of the sodium-potassium pump by the beta receptor
, with enhanced transport of potassium from the extracellular to the intracellular compartment.
Mice with a targeted mutation in the thyroid hormone beta receptor
gene exhibit impaired growth and resistance to thyroid hormone.
Though mice without the beta receptor
can live, they are plagued by a list of health problems--a list that continues to grow as researchers observe the mice aging.
An anti-lymphotoxin beta receptor
(LTBR) monoclonal antibody.
CDP 860 (PEGylated Anti-PDGF beta-receptor antibody fragment) is a PEGylated humanized antibody fragment that specifically binds to and blocks the beta receptor
for Platelet Derived Growth Factor (PDGF).
Dr Chris Wood, President & CEO, commented: "We have made substantial progress over the last nine months, in which we signed a co-development agreement with ILEX Oncology Inc, (NASDAQ:ILXO) for the development of clofarabine, and made considerable progress in continuing development of Modrenal(R) and Modrestane(R), which are the first commercially available drugs in a new class of agents that are active on the ER beta receptor
Beta-blockers intervene by preventing adrenaline from binding to alpha and beta receptors
From a biochemistry standpoint, beta receptors
exist in the heart and blood vessels as well as in other tissues throughout the body.
ol activity by binding to both alpha and beta receptors
, FemFlavone supports healthy estrogen levels and promotes overall wellness during menopause
In fact function of alpha and beta receptors
of estrogen influence on kidney cells.
There are three recognized subtypes of adrenergic beta receptors
Alpha receptors are the ones that cause relaxation of smooth muscles around bronchial tubes when stimulated, while stimulation of beta receptors
increases heart activity.
The blood samples of the family members were sent to Chicago University, USA to search for possible genetic mutations in thyroid hormone beta receptors
, since the laboratory findings in family members was compatible with PTHR