There have been reports of other labs deriving beta cell
types from stem cells, but no other group has produced mature beta cells
as suitable for use in patients," he said.
Unlike other research that has focused on how to replicate beta cells
, this study focused on how to make pre-existing beta cells
more functional, or better at secreting insulin.
In the new study, Herold and his colleagues found that mice that had high blood glucose--a sign that their remaining beta cells
were making very little insulin--didn't benefit any more from combined therapy than they did from the anti-CD3 alone.
While alpha cells converting into beta cells
had been described before, this was the first time an existing drug had been reported to stimulate the process and it caused a lot of excitement in the field, Huising said.
1 In type I diabetes, the environmental and nutritional factors induce oxidative stress and alter immune response by mediating the gene expression of cytokines which thrusts immune medicated beta cell
Editor's Note: As potential mechanisms, the authors note that zinc is needed for insulin's action, for carbohydrate metabolism, to moderate inflammatory cytokine levels that can destroy beta cells
, for preventing human islet amyloid polypeptides from aggregating to form amyloid fibers that have a toxic effect on beta cells
, to reduce oxidative stress and for other protective functions.
Dual role of proapoptotic BAD in insulin secretion and beta cell
In autoimmune diseases, it is thought that deficient Treg activity permits the T effector cells to attack the body's own beneficial cells, and in the case of T1D, insulin-producing pancreatic beta cells
mass dynamics in Zucker diabetic fatty rats, Rosiglitazone prevents the raise in net cell death.
function is closely related with insulin resistance.
High rates of beta cell
replication during the neonatal period results in a massive increase in the cell mass (Georgia and Bhushan, 2004).
I've never seen any treatment that causes such an enormous leap in beta cell
Islet beta cell
expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsuli nemia.
profiling of selected mouse strains using novel C-peptide and proinsulin ELISAs.
The team, from the Royal College of Surgeons and the Mater hospital, have identified a cell in the body called a beta cell
which produces insulin.