The pars intermedia of the hypophysis in Bactrian camel was narrow situated between the pars distalis and the pars nervosa, approximately 730 um in thickness, and composed of basophil cells and many crevices with different sizes.
In recent years, it has been emphasized that antiIgE (omalizumab) monoclonal antibody treatment among new treatment options acts by specifically binding to IgE antibody preventing binding with highly sensitive IgE receptors and thus highly sensitive IgE receptors expressed on mast and basophil cells decrease by negative feedback and omalizumab is useful in treatment of chronic urticaria (14,29-34).
In addition, POMx suppressed the NF-kappaB activation induced by PMACI by inhibiting IkappaB-degradation in human basophil cells. POMx also suppressed the powerful induction of NF-kappaB promoter-mediated luciferase activity in transiently transfected KU812 cells.
Type Ib (anaphylactoid) responses result in an antibody-antigen reaction at the surface of the sensitized cells, triggering the release of other mediators through degranulation of mast cells or basophil cells. Even though not involved in the immediate reaction, cells are attracted to the site of reaction by specific chemotactic factors.