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Other substituents attached to the ring (including selenium) can increase this strain further, which in turn increases the likelihood of bacterial enzymes opening it.
The amended agreement provides an option for GSK to expand its rights around the bacterial enzyme target LeuRS in return for a milestone payment ranging from $5.
As early as the 1960s, researchers knew that the bacterial enzyme beta-glucoronidase converts a plant chemical called cycasin into a carcinogen.
It produces blue colonies on MI Blue under ambient light doe to the breakdown of IBDG by the bacterial enzyme [beta]-Glucurondase.
Sulfamethoxazole inhibits dihydropteroate synthase, the bacterial enzyme that catalyzes the incorporation of p-aminobenzoid acid into dihydropteroic acid, the immediate precursor of folic acid, while trimethoprim was specifically synthesized as an inhibitor of dihydrofolate-reductase (40).
The bacterial enzyme unwittingly acts as a device that hides the enemy, he says--perhaps even encouraging the bacteria to take in more of the toxic drug than they ordinarily would.
GSK '052 specifically targets the bacterial enzyme leucyl-transfer RNA synthetase, or LeuRS, which is required for protein synthesis.
The particular protein-protein interaction is the phosphohistidine/phosphothreonine-dependent interaction of the plant and bacterial enzyme, PPDK, with its regulatory protein PDRP.
6 September 2011 - US Anacor Pharmaceuticals (NASDAQ:ANAC) said today it has amended and broadened its research and development partnership with UK GlaxoSmithKline (LON:GSK) to provide GSK the option to extend its rights around the bacterial enzyme target leucyl-tRNA synthetase (LeuRS), as well as to add new programmes for tuberculosis (TB) and malaria using Anacor's boron chemistry platform.
Spores of the bacterium are injected into the patient's body and only grow in solid tumours, where a specific bacterial enzyme is produced, along with an anti-cancer drug being injected separately into the patient in an inactive "pro-drug" form.
coli produces blue colonies on MI Blue under ambient light due to the breakdown of IBDG by the bacterial enzyme b-Glucurondase.
They hit on a way to attach an extra molecule to penicillin which is easily sliced off by the bacterial enzyme.
The DeltaTRAK FlashCheck([R]) Real-Time Bacterial Enzyme Detection kits include products that can screen for the presence of harmful bacteria on surfaces of equipment and food.
Washington, July 29 (ANI): A team of scientists, which included two middle school students from Wisconsin, US, is reporting the first glimpse of the innermost structure of a key bacterial enzyme.
AN3365 is a novel boron-based, small-molecule product candidate that targets the bacterial enzyme leucyl tRNA synthetase.