Autonomic & Autacoid
Pharmacology23 (5-6): 319-26.
Secreted IL-1[beta] also acts in an autacoid
manner, to engage IL-1[beta] receptors, activate the signaling molecule MyD88, and stimulate additional inflammatory reactions.
Each of these substances has vasodilator actions, and it is possible that AT2R stimulation leads to vasodilation through this autacoid
cascade (Carey et al.
It modulates the expression of proinflammatory genes transcription for cytokines, growth factors, adhesion molecules, nitric oxide, prostanoids and autacoids
The course contents included general pharmacology, autonomic nervous system, cardiovascular system, central nervous system, gastrointestinal tract, blood, autacoids
, respiratory system, endocrine system and chemotherapeutic agents.
Cyclooxygenase (COX) enzyme is responsible for the biosynthesis of the prostaglandins and certain related autacoids
and is considered to be a major component of the mechanism of NSAIDs.