sup] However, the exact mechanism(s) underlying miR-106b-5p in the atherogenesis
remain(s) poorly understood.
Another therapeutic strategy implicates a "direct" therapy, which is aimed to prevent the onset and progression of atherosclerotic lesions by inhibiting the molecular and cellular mechanisms of atherogenesis
in human arteries (Orekhov and Tertov 1997; Orekhov et al.
Neopterin stimulates nuclear factor-kB translocation to the nucleus promoting the expression of proinflammatory genes, adhesion molecules, tissue factor, and other substances implicated in the inflammatory processes that take place within the arterial wall in atherogenesis
and atheromatous plaque disruption.
51-53) Therefore, colchicine therapy may be responsible for less aggressive course of atherogenesis
in most studies on FMF.
To the best of our knowledge, this was the first evidence that P4H[alpha]1 overexpression regulates the process of atherogenesis
under low/oscillatory shear stress.
Monocyte/ macrophage suppression in CD11b diphtheria toxin receptor transgenic mice differentially affects atherogenesis
and established plaques," Circulation Research, vol.
In this manner, the present study aimed to verify the effect of propolis alone and its association with swimming in dyslipidemia, left ventricular hypertrophy and atherogenesis
of hypercholesterolemic mice that were receiving high-fat diet.
In terms of the role of IgG4-positive lymphocytes in coronary atherogenesis
, it would be of relevance to determine whether the thickened intima was positive for infiltration of such cells in the case of Patel et al.
The second part looks at cardiovascular, metabolic, and neurodegenerative conditions, beginning with a discussion of critical illness but then moving on to atrial fibrillation, atherogenesis
, insulin resistance and diabetes, transplant rejection, and a general review of neurodegeneration.
Patients have high levels of sympathetic excitation, oxidative stress, inflammatory mediators, endothelial dysfunction, and attenuated endothelial repair, which all can promote atherogenesis
, hypertension, arrhythmogenesis, and cardiac death, the researchers noted.
Hepcidin-mediated macrophage iron loading is essential for atherogenesis
Increased uptake of cholesterol in diet usually is a cause of atherogenesis
leading to narrowing of the vessels then to hypoxia of cardiac muscles and finally to IHD.
This establishes 5'-nucleotidase-derived adenosine as a direct or indirect regulator of atherogenesis
"as discussed elsewhere (Boring, Y.
6] reported that the reduction of the capacity of endothelium to generate NO occurs with the passage of years, depending on many factors and promotes the formation of atherosclerotic plaque in the process of atherogenesis
, leading to the development of inter alia Alzheimer's disease.
In the early phase of atherogenesis
these are monocyte chemotactic protein-1 (MCP-1), localized in atherosclerotic lesions, IL-8, interleukin-16 (IL-16), and C5a-receptor fragment peptide, released in hypercholesterolemia .