Nephron segments of the renal medulla include the proximal straight tubule, descending and ascending thin limbs of Henle's loop, thick ascending limbs
, and the medullary collecting ducts (Fig.
These drugs have their effect on the sodium-potassium-chloride symporter (Cotransporter) in the thick ascending limb
of the loop of Henle.
Stimulation on the ascending limb
was related to drinking in the past month for African Americans but not for whites.
This was based on the observation of a sodium wasting defect paralleling preserved ascending limb function .
cotransporter (NKCC2) of the thick ascending limb (TAL).
The loop of Henle consists of several segments including the thin descending limb, the thin ascending limb of Henle, and the thick ascending limb.
As tubular fluid moves into the thick ascending limb, more [Na.
The fluid becomes more dilute as it moves into the thick ascending limb
, which is impermeable to water and urea, but actively reabsorbs NaCl.
Eulamellibranchs possess two types of tissue bridges: 'interfilamentar junctions' (also septa) between the descending and ascending limbs
of the filaments, and 'interfilamentar junctions' between adjacent filaments.
Approximately 80% of the filtered bicarbonate is reabsorbed in the proximal tubule, 15% in the thick ascending limb
, and 5% in the collecting duct.
The thick ascending limb
of the loop of Henle is the principle site of magnesium reabsorption, where 50%-65% of the filtered load is reabsorbed.
Approximately 60%-70% of the filtered load is reabsorbed in the proximal tubule, 20% in the thick ascending limb
of Henle's loop, and 5%-10% in the distal tubule.
The loop of Henle is the next component of the tubular system and consists of the thin descending limb, thin ascending limb
, and thick ascending limb