Change in joint space width: Hyaline articular cartilage
loss or alteration in meniscus?
Factors affecting articular cartilage
thickness in osteoarthritis and aging.
1-4) indicating that MIA plus STZ caused severe destruction of the articular cartilage
(Figs 1-3) and upregulation of TNF-?
Clinical and radiological studies that link synovial inflammation to articular cartilage
structural injury and JSN have been complemented by basic science studies that explore this relationship.
Some studies have introduced populations of stem/progenitor cells in the synovial membrane (16,17) and articular cartilage
, (18-20) which show characteristic of stem cells and have the potential for cartilage repair.
Osteoarthritis proceeds gradually, weakening the articular cartilage
and ultimately wearing it off completely from the ends of articulating bones.
Degenerative (arthritic) changes are often present in the articular cartilage
in conjunction with the meniscus tear; these changes are manifested as potholes or ruts in the cartilage, ranging from a small scuff in the cartilage to a lesion that extends the depth of the cartilage.
The potential for regeneration of articular cartilage
in defects created by chondral shaving and subchondral abrasion.
The blood supply to the capitellum is limited as its main blood supply enters posteriorly, traversing the epiphyseal articular cartilage
with no metaphyseal collateral contribution.
The articular cartilage
of the left knee was exposed via the medial parapatellar approach, which revealed that the entire articular cartilage
exhibited severe black pigmentation and that the synovial membrane was also pigmented (Figure 2(a)).
GlobalData's clinical trial report, "Articular Cartilage
Defect Global Clinical Trials Review, H2, 2015" provides an overview of Articular Cartilage
Defect clinical trials scenario.
Samples were placed in two different blocks as follows: The first block included 1 cm of ossified medial clavicle, articular cartilage
, joint, sternum's articular cartilage
, and 1 cm of sternum.
Relative to healthy-weighted peers, obese individuals experience greater vertical ground reaction forces (GRF) and altered GRF characteristics (Nimbarte and Li, 2011), which likely influences knee load and accelerates articular cartilage
degradation (Creaby et al.
Until now, this type of exercise was thought to be harmful for the knee's articular cartilage
Multiple studies have been conducted with the objective of repairing articular cartilage
lesions in symptomatic patients.