induces apoptosis of human monocytes during macrophagic differentiation through nuclear Factor-KB-related survival pathway down-regulation.
Tumor growth inhibition by arsenic trioxide
(As2Os) in the orhtotopic metastasis model of androgen-independent prostate cancer.
is generated from processing arsenic compounds, and while a high level of arsenic is known to be carcinogenic, low doses can be therapeutic in selected patients, said Uren.
Lead researcher Dr Ardeshir Ghavamzadeh said: 'There have been a few studies done using arsenic trioxide
on a limited number of newly diagnosed patients, but we are the first group to suggest that it is acceptable as a first-line treatment.
The goals of this project are: (1) to determine the toxicity of arsenic trioxide
using the lactate dehydrogenase (LDH) assay; (2) to determine the cellular response mechanism of arsenic in human hepatic carcinoma cell line (HepG2); and (3) to assess the genotoxic effects of arsenic in HepG2 cells.
Sodium arsenite and arsenic trioxide
differently affect the oxidative stress, genotoxicity and apoptosis in A549 cells: an implication for the paradoxical mechanism.
inhibits the growth of A498 renal cell carcinoma cells via cell cycle arrest or apoptosis.
has been used as a therapy for a particular type of leukemia for more than 10 years.
From Datta et al, the authors found that pre- and post-feeding of homoopathically prepared Arsenicum album 30C and 200C to mice exposed to arsenic trioxide
reduced the genotoxic effects (chromosome aberrations, micronucleated erythrocytes and sperm head anomaly) of arsenic when compared to con trols (26).
NCS is a major producer of arsenic trioxide
, a substance which is sold in increasing quantities to the agri-chemical industry, and negotiations are underway to increase the volumes supplied under the current contract with Amcrop, the Malaysian company," the company said.
24) The volume of research that supports the use of AA in combination with chemotherapy is even greater if the research of the use of AA in combination with Arsenic trioxide
Various ECG abnormalities, such as QRS complex broadening, prolonged QT intervals, ST segment depressions, T-wave flattening, and even ventricular tachycardia, had been observed among cases of acute arsenic poisoning and in acute promyelocytic leukaemia patients treated with arsenic trioxide
Where a history of bankrupt gold mines has left behind 250,000 metric tonnes of arsenic trioxide
in leaky underground vaults -- enough to kill all life in the Mackenzie Valley.
These 10 most reported carcinogens were arsenic, arsenic trioxide
, asbestos, benzene, benzidine, lead chromate, sodium arsenate, sodium arsenite, sodium dichromate, and vinyl chloride (3,4).
The new two-stage fluidized-bed roasting plant at New Consort commissioned in June 1988 treats 4 mt/hr dry-solids as a slurry with recovery of arsenic trioxide
as by-product and the conversion of off-gases to sulphuric acid.