At four months, he began arsenic trioxide
therapy via intravenous with 8mg/250cc.
QT interval prolongation: Patients receiving arsenic trioxide
may be at risk for prolonged QT interval, which can lead to a fatal ventricular arrhythmia.
as an inducer of apoptosis and loss of PML/RAR [alpha] protein in acute promyelocytic leukemia cells.
Objective (2) to establish the role of arsenic trioxide
in transactivation of p53-responsive genes in relation to PFT-alpha protection and objective (3) to provide basis for elucidating the potential mechanisms involved in arsenic/cadmium-induced hepatotoxicity.
works by causing changes in cancer cells which induce apoptosis - programmed cell death, and appears to correct the gene which makes flawed protein causing APL.
Certificate of Analysis, SRM 83d, Arsenic Trioxide
The lethal dose of inorganic arsenic is 100-200 mg of arsenic trioxide
for an adult individual, although people have survived larger doses (2, 3).
The findings from the phone survey included use of arsenic, arsenic trioxide
, asbestos, benzene, lead chromate, sodium arsenate, and sodium dichromate in pure form for science or chemistry experiments or demonstrations.
in hematological malignancies: the new discovery of an ancient drug.
The topics include arsenic's interactions with macromolecules and its relationship to carcinogenesis, the biological chemistry of antimony and bismuth, arsenic in traditional Chinese medicine, metalloid transport systems, Helicobacter pylori and bismuth, application of arsenic trioxide
therapy for patients with leukemia, radio-bismuth for therapy, and genetic toxicity in arsenic and antimony.
They further detailed how they used an existing drug, arsenic trioxide
(Trisenox), to shut down that pathway in mice models of ES and medulloblastoma.
The stem lengths of the seedlings was assessed at day 7 and it was found that the 45X potencies of Arsenicum and the water but not the diluted arsenic trioxide
induced an increase in seedling height.
The European Commission designated the medicinal product arsenic trioxide
an orphan drug in October 2000.
We know from past research that arsenic trioxide
inhibits growth in certain tumors through its activity against the Hedgehog pathway," commented Joseph Bertino, M.
Zhu Chen, a former student of Wang, made major contributions to the identification of the molecular mechanisms of both ATRA and arsenic trioxide