At ~10% inhibition, LH peaks disappear after approximately five cycles, and a major bifurcation in cycle patterns occurs: cycles are further shortened, baseline levels are much increased (doubled for E2 and P4, for example, even though E2 synthesis by aromatase is
decreased), and peak levels mostly decreased; E2 distance to normal increases up to a maximum (Figure 2).
ABSTRACT: Cytochrome P450 aromatase is
responsible for the biosynthesis of estrogen.
the enzyme that helps the body make estrogen.
As shown in Figure 3A, FSH-induced aromatase is
down-regulated with increasing concentrations of the PPAR[gamma] vector, and there was a similar trend of IGF-1 down-regulation (Figure 3C).
a key enzyme in the synthesis of estrogen.
It has been hypothesized that altered expression of aromatase is
important in environmentally influenced sex differentiation.
This aromatase is
expressed in the human prostate, suggesting a local role for estrogen.
Thus, a decrease in aromatase is
expected to lead in part to build up of male hormones, which, in turn, further decrease RORA expression, as demonstrated in this study using a neuronal cell model.