In vitro inhibitory effects of favipiravir and ribavirin against Arenaviruses
(Based on Gowen et al.
Ebola could have mixed with arenaviruses
long ago, resulting in the combination snake virus.
However, the human health implications of arenaviruses
are less clear.
Add viral hemorrhagic fever caused by Ebola or Marburg viruses, Lassa virus, New World Arenaviruses
(Guanarito, Machupo, Junin, Sabia), or Crimean-Congo hemorrhagic fever to the nationally notifiable condition list.
They also focus on the activation and evasion of host antiviral signaling pathways by detailing RNA virus families, filoviruses, suppression of innate immunity, paramyxovirus and orthomyxoviruses, arenaviruses
, picornaviruses, togaviruses, coronaviruses and innate immune responses elicited by reovirus and rotavirus.
The new Chapare arenavirus, discovered in serum samples from a patient in rural Bolivia who eventually died of the infection, produces clinical hemorrhagic symptoms similar to those associated with other New World arenaviruses
Junin, Machupo, and Guanarito.
Hantaviruses and arenaviruses
are also known as roboviruses.
Characterization of arenaviruses
using a family-specific primer set for RT-PCR amplification and RFLP analysis.
The CDC also has identified an "A" list of biological agents of highest concern, which includes (a) variola major (smallpox), (b) Bacillus anthracis (anthrax), (c) Yersinia pestis (plague), (d) Francisella tularensis (tularemia), (e) botulinum toxin (botulism), and (f) filoviruses and arenaviruses
(viral hemorrhagic fevers).
UTMB has one of the few laboratories in the coun try equipped to test for arenaviruses
include Lassa fever and lymphocytic choriomeningitis.
Current disease and virus targets include hepatitis C virus (HCV), human papilloma virus (HPV), herpes simplex virus type 2 (HSV-2), human immunodeficiency virus (HIV), Ebola virus, Marburg Virus, the arenaviruses
Laboratory diagnosis consisted of testing for filoviruses, arenaviruses
, and bunyaviruses, as well as for Chikungunya and dengue viruses by using reverse transcription PCR (RT-PCR).
Focusing on arenaviruses
, these genome-wide surveys will reveal host factors indicative of virus entry tactics never observed before.
According to the company, BCX4430 is an RNA dependent-RNA polymerase inhibitor that has demonstrated broad-spectrum activity against more than 20 RNA viruses in nine different families, including filoviruses, togaviruses, bunyaviruses, arenaviruses
, paramyxoviruses, coronaviruses and flaviviruses.